Source:http://linkedlifedata.com/resource/pubmed/id/18033318
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0005767,
umls-concept:C0008059,
umls-concept:C0013216,
umls-concept:C0023449,
umls-concept:C0035020,
umls-concept:C0035168,
umls-concept:C0037047,
umls-concept:C0040732,
umls-concept:C0205099,
umls-concept:C0205409,
umls-concept:C0332835,
umls-concept:C0376152,
umls-concept:C0544452,
umls-concept:C0681804,
umls-concept:C0927232,
umls-concept:C1274040,
umls-concept:C1512888,
umls-concept:C1516477
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| pubmed:issue |
2
|
| pubmed:dateCreated |
2008-2-13
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| pubmed:abstractText |
In children with acute lymphoblastic leukemia (ALL) with isolated central nervous system (CNS) relapse and a human leucocyte antigen (HLA)-matched sibling, the optimal treatment after attaining second remission is unknown. We compared outcomes in 149 patients enrolled on chemotherapy trials and 60 HLA-matched sibling transplants, treated in 1990-2000. All patients achieved a second complete remission. Groups were similar, except the chemotherapy recipients were younger at diagnosis, less likely to have T-cell ALL and had longer duration (> or = 18 months) first remission. To adjust for time-to-transplant bias, left-truncated Cox's regression models were constructed. Relapse rates were similar after chemotherapy and transplantation. In both treatment groups, relapse rates were higher in older children (11-17 years; RR 2.81, P=0.002) and shorter first remission (< 18 months; RR 3.89, P<0.001). Treatment-related mortality rates were higher after transplantation (RR 4.28, P=0.001). The 8-year probabilities of leukemia-free survival adjusted for age and duration of first remission were similar after chemotherapy with irradiation and transplantation (66 and 58%, respectively). In the absence of an advantage for one treatment option over another, the data support use of either intensive chemotherapy with irradiation or HLA-matched sibling transplantation with total body irradiation containing conditioning regimen for children with ALL in second remission after an isolated CNS relapse.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
1476-5551
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| pubmed:author |
pubmed-author:BarredoJ CJC,
pubmed-author:CamittaB MBM,
pubmed-author:CarrollW LWL,
pubmed-author:Center for International Blood and Marrow Transplant Research,
pubmed-author:Children's Oncology Group,
pubmed-author:DaviesS MSM,
pubmed-author:DevidasMM,
pubmed-author:EapenMM,
pubmed-author:GodderKK,
pubmed-author:GruppSS,
pubmed-author:LewisV AVA,
pubmed-author:MallonFF,
pubmed-author:RaetzEE,
pubmed-author:RitcheyA KAK,
pubmed-author:ZhangM-JMJ
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
22
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
281-6
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| pubmed:meshHeading |
pubmed-meshheading:18033318-Adolescent,
pubmed-meshheading:18033318-Antineoplastic Agents,
pubmed-meshheading:18033318-Bone Marrow Transplantation,
pubmed-meshheading:18033318-Central Nervous System Neoplasms,
pubmed-meshheading:18033318-Child,
pubmed-meshheading:18033318-Child, Preschool,
pubmed-meshheading:18033318-Data Collection,
pubmed-meshheading:18033318-Disease-Free Survival,
pubmed-meshheading:18033318-Female,
pubmed-meshheading:18033318-HLA Antigens,
pubmed-meshheading:18033318-Histocompatibility,
pubmed-meshheading:18033318-Humans,
pubmed-meshheading:18033318-Leukemic Infiltration,
pubmed-meshheading:18033318-Longitudinal Studies,
pubmed-meshheading:18033318-Male,
pubmed-meshheading:18033318-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:18033318-Radiotherapy,
pubmed-meshheading:18033318-Recurrence,
pubmed-meshheading:18033318-Remission Induction,
pubmed-meshheading:18033318-Siblings,
pubmed-meshheading:18033318-Transplantation Conditioning,
pubmed-meshheading:18033318-Treatment Outcome
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
Outcomes after HLA-matched sibling transplantation or chemotherapy in children with acute lymphoblastic leukemia in a second remission after an isolated central nervous system relapse: a collaborative study of the Children's Oncology Group and the Center for International Blood and Marrow Transplant Research.
|
| pubmed:affiliation |
Department of Medicine, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI 53226, USA. meapen@mcw.edu
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, N.I.H., Extramural
|