Linked Life Data

18029666

Source:http://linkedlifedata.com/resource/pubmed/id/18029666

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
51
pubmed:dateCreated
2007-11-21
pubmed:abstractText
Ionizing radiation induces clustered DNA damage, which contains localized multiple lesions in duplex DNA molecules. It has been thought that due to complex nature, clustered DNA damage is refractory to repair or associated with error-prone repair and results in severe biological endpoints as compared to sparsely-distributed lesions. High linear energy transfer (LET) radiations such as heavy ion beams exert a greater relative biological effect (RBE) than low LET radiations such as X- and gamma-rays. In the present study, we analyzed the yields of clustered DNA damage produced by high and low LET radiations using in vitro and in vivo systems and examined whether the differential formation of clustered DNA damage accounts for distinct RBE values of these radiations.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1746-8272
pubmed:author
pubmed:issnType
Electronic
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
221-2
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Analysis of complex DNA lesions generated by heavy ion beams.
pubmed:affiliation
Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima 739-8526, Japan. hterato@hiroshima-u.ac.jp
pubmed:publicationType
Journal Article