Linked Life Data

1802924

Source:http://linkedlifedata.com/resource/pubmed/id/1802924

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1992-4-24
pubmed:abstractText
The presence of gastrin in pituitary tissue as well as gastrin hypersecretion by some pituitary adenomas have been documented using different methodological approaches. In the present study, serum gastrin levels were measured in 93 patients with nonfunctioning pituitary adenoma, i.e. a condition lacking a reliable marker of the disease. Elevated gastrin levels (85-2, 180 ng/l; normal range: 15-80 ng/l) were found in 14/93 patients (15%), the highest values being observed in one patient with MEN I syndrome. In all but MEN I hypergastrinemic patient, a severe gastric hypochlorhydria (Basal Acid Output: 0.04 +/- 0.1 mmol H+/h) unresponsive to pentagastrin (Maximum Acid Output: 0.1 +/- 0.2 mmol H+/h) was seen. Secretin injection caused gastrin to increase in the patient with MEN I and in another hypergastrinemic patient. Antiparietal cells autoantibodies were positive in 3/11 patients. No changes in gastrin concentrations were found after administration of several agents usually employed in the evaluation of pituitary function, except a significant gastrin reduction after octreotide injection. In two hypergastrinemic patients who underwent pituitary adenomectomy, the high gastrin levels did not change after surgery. Finally, gastrin was undetectable in the culture media of 15 pituitary adenomas surgically removed from both normo- and hypergastrinemic patients and immunocytological studies of tumor cells did not show any gastrin staining. In conclusion, although in patients with pituitary adenomas serum gastrin evaluation is indicated in order to document the presence of a MEN I syndrome, the present data show that high gastrin levels cannot be taken as a specific marker of nonfunctioning pituitary adenomas unless the peripheral origin of hypergastrinemia is excluded.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0391-4097
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
861-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:1802924-Adenoma, pubmed-meshheading:1802924-Adult, pubmed-meshheading:1802924-Aged, pubmed-meshheading:1802924-Analysis of Variance, pubmed-meshheading:1802924-Bromocriptine, pubmed-meshheading:1802924-Corticotropin-Releasing Hormone, pubmed-meshheading:1802924-Female, pubmed-meshheading:1802924-Gastrins, pubmed-meshheading:1802924-Gonadotropin-Releasing Hormone, pubmed-meshheading:1802924-Growth Hormone-Releasing Hormone, pubmed-meshheading:1802924-Humans, pubmed-meshheading:1802924-Male, pubmed-meshheading:1802924-Middle Aged, pubmed-meshheading:1802924-Octreotide, pubmed-meshheading:1802924-Pentagastrin, pubmed-meshheading:1802924-Pituitary Gland, pubmed-meshheading:1802924-Pituitary Neoplasms, pubmed-meshheading:1802924-Secretin, pubmed-meshheading:1802924-Thyrotropin-Releasing Hormone, pubmed-meshheading:1802924-Tumor Markers, Biological
pubmed:year
1991
pubmed:articleTitle
Patterns of gastrin secretion in patients with nonfunctioning pituitary adenomas.
pubmed:affiliation
Istituto di Scienze Endocrine, CNR, Milano, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't