Source:http://linkedlifedata.com/resource/pubmed/id/18025761
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2008-2-20
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| pubmed:abstractText |
Determinants of glucose intolerance were studied in 163 obese Japanese young adults, 18 to 21 years old (43 females,120 males), who underwent 75-g oral glucose tolerance testing. Type 2 diabetes was newly diagnosed in 2.9% (n = 4); impaired fasting glucose (IFG) in 5.1% (n = 7); and impaired glucose tolerance (IGT) in 10.9% (n = 15). A homeostasis model assessment of insulin resistance (HOMA-IR) was used to estimate insulin sensitivity; beta-cell function during the first 30 min of the test was measured and defined as the insulinogenic index. This index was adjusted for insulin sensitivity, since this affects both beta-cell function and glucose disposition (disposition index). The relationship between insulinogenic index and 1/HOMA-IR was not hyperbolic. However, the disposition index (DI) was useful for the estimation of beta-cell function with the correct confirmation about it validity using beta-cell function index (BI). The association between insulin sensitivity and beta-cell function to glucose disposal, as measured by the area under the glucose curve (AUCg), was examined in all subjects. Insulin sensitivity was significantly related to AUCg (log HOMA-IR; R (2) = 0.142, p<0.0001). On the other hand, an inverse curvilinear relationship was observed between beta-cell function and AUCg (log(Delta I/Delta G)/HOMA-IR, R (2) = 0.411, p<0.0001). Thus, impaired beta-cell function, when estimated as DI, was strongly associated with impaired glucose disposal. In conclusion, our study showed that both insulin sensitivity and impaired beta-cell function are associated with impaired glucose metabolism, and that beta-cell function may be more important in determining glucose disposal.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
1348-4540
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| pubmed:author |
pubmed-author:AkehiYuhkoY,
pubmed-author:AnzaiKeizoK,
pubmed-author:AsanoTakashiT,
pubmed-author:HidehiraKiyomiK,
pubmed-author:KikuchiMasahiroM,
pubmed-author:KokawaKazuhikoK,
pubmed-author:OgataHideakiH,
pubmed-author:OgimotoMasaoM,
pubmed-author:OnoJunkoJ,
pubmed-author:TamuraKazuoK,
pubmed-author:YoshidaRyokoR
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| pubmed:issnType |
Electronic
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| pubmed:volume |
54
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
903-10
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:18025761-Administration, Oral,
pubmed-meshheading:18025761-Adolescent,
pubmed-meshheading:18025761-Adult,
pubmed-meshheading:18025761-Area Under Curve,
pubmed-meshheading:18025761-Blood Glucose,
pubmed-meshheading:18025761-Cholesterol,
pubmed-meshheading:18025761-Cross-Sectional Studies,
pubmed-meshheading:18025761-Female,
pubmed-meshheading:18025761-Glucose,
pubmed-meshheading:18025761-Glucose Intolerance,
pubmed-meshheading:18025761-Glucose Tolerance Test,
pubmed-meshheading:18025761-Humans,
pubmed-meshheading:18025761-Insulin,
pubmed-meshheading:18025761-Insulin Resistance,
pubmed-meshheading:18025761-Insulin-Secreting Cells,
pubmed-meshheading:18025761-Japan,
pubmed-meshheading:18025761-Male,
pubmed-meshheading:18025761-Obesity,
pubmed-meshheading:18025761-Triglycerides
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| pubmed:year |
2007
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| pubmed:articleTitle |
Beta-cell function is a major contributor to oral glucose disposition in obese Japanese students.
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| pubmed:affiliation |
Medical Health Center, Fukuoka University, Fukuoka, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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