Linked Life Data

18025391

Source:http://linkedlifedata.com/resource/pubmed/id/18025391

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
21
pubmed:dateCreated
2007-11-20
pubmed:abstractText
In patients with Parkinson disease (PD), transcranial magnetic stimulation (TMS) studies have consistently demonstrated a reduced inhibitory tone in the sensorimotor cortex. It remains unclear whether this is related to motor symptoms or represents adaptive compensatory changes to degeneration of dopaminergic neurons. Here we used short-interval afferent inhibition after digital stimulation (dSAI) and intracortical paired-pulse inhibition and facilitation to probe intracortical sensorimotor excitability in clinically asymptomatic carriers of a single mutant Parkin allele who have a latent nigrostriatal dopaminergic dysfunction.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1526-632X
pubmed:author
pubmed:issnType
Electronic
pubmed:day
20
pubmed:volume
69
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1976-81
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Sensorimotor integration is abnormal in asymptomatic Parkin mutation carriers: a TMS study.
pubmed:affiliation
Department of Neurology, University of Hamburg, Martinistrasse 52, 20246 Hamburg, Germany. baeumer@uke.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't