Linked Life Data

18024575

Source:http://linkedlifedata.com/resource/pubmed/id/18024575

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-2-14
pubmed:abstractText
SUMMARY: In this first article, we review the basic principles of using reporter genes for molecular imaging of the brain in living subjects. This approach is emerging as a valuable tool for monitoring gene expression in diverse applications in laboratory animals, including the study of gene-targeted and trafficking cells, gene therapies, transgenic animals, and more complex molecular interactions within the central nervous system. Further development of more sensitive and selective reporters, combined with improvements in detection technology, will consolidate the position of in vivo reporter gene imaging as a versatile method for greater understanding of intracellular biologic processes and underlying molecular neuropathology and will potentially establish a future role in the clinical management of patients with neurologic diseases.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1936-959X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
229-34
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Noninvasive molecular neuroimaging using reporter genes: part I, principles revisited.
pubmed:affiliation
Department of Radiology, Section of Neuroradiology, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, UK. tfm23@radiol.cam.ac.uk
pubmed:publicationType
Journal Article, Review