Using transcranial B-mode sonography (TCS), the first morphological marker for restless legs syndrome (RLS), hypoechogenicity of the substantia nigra (SN) has been found. The aim of this study was to validate SN hypoechogenicity as a morphological marker for RLS in a large patient cohort and to investigate further RLS-associated brain abnormalities using TCS.
Hertie Institute for Clinical Brain Research and Center of Neurology, Department of Neurodegeneration, Hoppe-Seyler-Str. 3, University of Tuebingen, 72076 Tuebingen, Germany. jana.godau@medizin.uni-tuebingen.de
