Linked Life Data

17998363

Source:http://linkedlifedata.com/resource/pubmed/id/17998363

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2007-11-13
pubmed:abstractText
The epithelial sodium channel (ENaC) represents the rate-limiting step of sodium absorption across airway epithelia and thereby constitutes the major pathway for volume absorption from the airway surface liquid compartment. ENaC dysregulation leads to dehydration of airway surfaces in patients with cystic fibrosis, which in turn disrupts the primary innate lung defense mechanism, mucus clearance. The development of treatment strategies that address this defect is a logical and promising means of preventing or delaying the onset of this lethal lung disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0012-3692
pubmed:author
pubmed:issnType
Print
pubmed:volume
132
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1631-6
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Sodium channels and cystic fibrosis.
pubmed:affiliation
Cystic Fibrosis Research and Treatment Center, 6007B Thurston Bowles Building, CB# 7248, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. scott_donaldson@med.unc.edu
pubmed:publicationType
Journal Article, Review