Linked Life Data

17991181

Source:http://linkedlifedata.com/resource/pubmed/id/17991181

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2007-11-9
pubmed:abstractText
For more than 10 years a vaccine against Helicobacter pylori has been the elusive goal of many investigators. The need for a vaccine was highlighted when eradication attempts in developing countries were foiled by reinfection rates of 15-30% per annum. In addition, physicians in developed countries were concerned that attempts at total eradication of H. pylori would result in widespread macrolide resistance in both H. pylori and other important pathogens. Although attempts to produce vaccines against H. pylori have failed in their ultimate goal, considerable knowledge has been developed on the pathogenesis and immunology of Helicobacter infections. In this article we describe an alternative use for this new knowledge, i.e. a plan to use live Helicobacter species to deliver vaccines against other organisms. Because of its intimate attachment to the gastric mucosa and long-term residence there, H. pylori might succeed as an antigen delivery system, a goal which has eluded most other strategies of nonparenteral vaccination.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1083-4389
pubmed:author
pubmed:issnType
Print
pubmed:volume
12 Suppl 2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
75-9
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Helicobacter pylori as a vaccine delivery system.
pubmed:affiliation
Helicobacter pylori Research Laboratory, Microbiology and Immunology, University of Western Australia, Perth, Western Australia, Australia. admin@hpylori.com.au
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't