Linked Life Data

17987796

Source:http://linkedlifedata.com/resource/pubmed/id/17987796

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2007-11-8
pubmed:abstractText
The mechanism of gastric cancer development and its etiology has not been completely elucidated so far. Macrophage Metalloelastase (HME) plays an important role in tumor growth, infiltration and metastasis. The aim of the present study was to investigate the expression of HME mRNA and protein in both gastric cancer cell lines and tumor specimens and evaluate its role in the development of gastric cancer, and its correlation with patient prognosis. Using Real-time PCR, Western Blot and Immunohistochemistry, we detected the HME mRNA and protein expression in gastric cancer cell lines and specimens, and further analyzed the association between HME expression and clinical data. The results showed that both HME mRNA and protein expression were found in all three gastric cancer cell lines. The expression of HME mRNA and protein in gastric cancer specimens was increased significantly compared with that in normal tissues (P<0.05). Meanwhile, the rate of lymph node metastasis of HME mRNA positive cases was lower than in HME negative ones (P<0.05); two-year survival rate in HME mRNA positive cases was higher than in HME negative ones (P<0.05). HME may be a novel gastric tumor biomarker and its expression in gastric cancers may be related with lower metastatization rates with conseguent better prognosis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0392-9078
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
361-6
pubmed:dateRevised
2009-11-3
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Human macrophage metalloelastase expression in gastric cancer and its relationship with gastric cancer prognosis.
pubmed:affiliation
Department of Gastroenterology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. zhanghong671013@126.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't