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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2007-11-7
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pubmed:abstractText |
Anorexia and weight loss are part of the wasting syndrome of late-stage cancer, are a major cause of morbidity and mortality in cancer, and are thought to be cytokine mediated. Macrophage inhibitory cytokine-1 (MIC-1) is produced by many cancers. Examination of sera from individuals with advanced prostate cancer showed a direct relationship between MIC-1 abundance and cancer-associated weight loss. In mice with xenografted prostate tumors, elevated MIC-1 levels were also associated with marked weight, fat and lean tissue loss that was mediated by decreased food intake and was reversed by administration of antibody to MIC-1. Additionally, normal mice given systemic MIC-1 and transgenic mice overexpressing MIC-1 showed hypophagia and reduced body weight. MIC-1 mediates its effects by central mechanisms that implicate the hypothalamic transforming growth factor-beta receptor II, extracellular signal-regulated kinases 1 and 2, signal transducer and activator of transcription-3, neuropeptide Y and pro-opiomelanocortin. Thus, MIC-1 is a newly defined central regulator of appetite and a potential target for the treatment of both cancer anorexia and weight loss, as well as of obesity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1078-8956
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pubmed:author |
pubmed-author:AppleFred SFS,
pubmed-author:BaldockPaul APA,
pubmed-author:BauskinAsne RAR,
pubmed-author:BreitSamuel NSN,
pubmed-author:BrownDavid ADA,
pubmed-author:CoreyEvaE,
pubmed-author:DuringMatthew JMJ,
pubmed-author:EnriquezRonaldo FRF,
pubmed-author:FairlieW DouglasWD,
pubmed-author:HerzogHerbertH,
pubmed-author:HunterMarkM,
pubmed-author:JiangLeleL,
pubmed-author:JohnenHeikoH,
pubmed-author:JunankarSimonS,
pubmed-author:KuffnerTamaraT,
pubmed-author:LeeNicola JNJ,
pubmed-author:LinEn-JuEJ,
pubmed-author:LinShuS,
pubmed-author:MurakamiMaryann MMM,
pubmed-author:PankhurstGregG,
pubmed-author:SainsburyAmandaA,
pubmed-author:TsaiVicky Wang-WeiVW,
pubmed-author:WangChuansongC,
pubmed-author:WuLiyunL
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pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1333-40
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17982462-Animals,
pubmed-meshheading:17982462-Anorexia,
pubmed-meshheading:17982462-Antibodies,
pubmed-meshheading:17982462-Cell Line, Tumor,
pubmed-meshheading:17982462-Cytokines,
pubmed-meshheading:17982462-Growth Differentiation Factor 15,
pubmed-meshheading:17982462-Humans,
pubmed-meshheading:17982462-Male,
pubmed-meshheading:17982462-Mice,
pubmed-meshheading:17982462-Mice, Inbred BALB C,
pubmed-meshheading:17982462-Mice, Inbred C57BL,
pubmed-meshheading:17982462-Mice, Nude,
pubmed-meshheading:17982462-Mice, Transgenic,
pubmed-meshheading:17982462-Multigene Family,
pubmed-meshheading:17982462-Prostatic Neoplasms,
pubmed-meshheading:17982462-Transforming Growth Factor beta,
pubmed-meshheading:17982462-Weight Loss
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pubmed:year |
2007
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pubmed:articleTitle |
Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1.
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pubmed:affiliation |
Centre for Immunology, St. Vincent's Hospital and University of New South Wales, Sydney, New South Wales 2010, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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