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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2008-1-10
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pubmed:abstractText |
Uterine smooth muscle cells exhibit ionic currents that appear to be important in the control of uterine contractility, but how these currents might produce the changes in contractile activity seen in pregnant myometrium has not been established. There are conflicting reports concerning the role of voltage-gated potassium (Kv) channels and large-conductance, calcium-activated potassium (BK) channels in the regulation of uterine contractility. In this study we provide molecular and functional evidence for a role for Kv channels in the regulation of spontaneous contractile activity in mouse myometrium, and also demonstrate a change in Kv channel regulation of contractility in pregnant mouse myometrium.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17980032-10420013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17980032-10440095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17980032-10486479,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17980032-10732311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17980032-10840032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17980032-10871603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17980032-11093945,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17980032-11319161,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17980032-11427525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17980032-11450426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17980032-12556357,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17980032-14302154,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17980032-14551239,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17980032-14657415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17980032-15972885,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17980032-1636679,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17980032-16415906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17980032-1694175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17980032-2456792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17980032-2561257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17980032-2859212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17980032-6703037,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17980032-727239,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17980032-7538700,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17980032-7542182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17980032-7679886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17980032-8271220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17980032-8498452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17980032-8575108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17980032-8756417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17980032-9316611,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17980032-9918782
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1477-7827
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
41
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17980032-4-Aminopyridine,
pubmed-meshheading:17980032-Animals,
pubmed-meshheading:17980032-Dose-Response Relationship, Drug,
pubmed-meshheading:17980032-Female,
pubmed-meshheading:17980032-Large-Conductance Calcium-Activated Potassium Channels,
pubmed-meshheading:17980032-Male,
pubmed-meshheading:17980032-Mice,
pubmed-meshheading:17980032-Mice, Inbred C57BL,
pubmed-meshheading:17980032-Myometrium,
pubmed-meshheading:17980032-Potassium Channels, Voltage-Gated,
pubmed-meshheading:17980032-Pregnancy,
pubmed-meshheading:17980032-Pregnancy, Animal,
pubmed-meshheading:17980032-Shal Potassium Channels,
pubmed-meshheading:17980032-Uterine Contraction
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pubmed:year |
2007
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pubmed:articleTitle |
The role of voltage-gated potassium channels in the regulation of mouse uterine contractility.
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pubmed:affiliation |
epartment of Pharmacology, Creighton University Medical Center, Omaha, USA, NE 68178, USA. rcsmith@creighton.edu
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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