Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2007-11-2
pubmed:abstractText
AR is considered as a risk factor for CAN after kidney TX. We combined data on AR with long-term graft function and histopathology to assess whether early treatment of AR is beneficial for long-term graft outcome in small children. Seventy-seven children with a mean age of 4.7 yr were studied. Early AR were diagnosed with FNAB and treated with methylprednisolone already before clinical signs occurred. The children were grouped into three groups (clinical, subclinical, and no AR) and then followed prospectively up to seven yr after TX with measured GFR and core needle biopsies to assess histopathological findings with the CADI score. Early AR, whether clinical or subclinical, did not affect long-term graft survival (80% with AR vs. 83% without AR, at 10 yr). Late AR, more than one yr after TX, had an inferior graft survival 50% vs. 84% (p = 0.02). GFR declined and the CADI scores increased with time, but there were no significant differences between the three groups. Prompt and early treatment of post-operative AR gives favorable long-term graft function compared with children without AR. Late AR is a risk factor for inferior long-term graft function.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1397-3142
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
895-900
pubmed:meshHeading
pubmed-meshheading:17976125-Acute Disease, pubmed-meshheading:17976125-Adolescent, pubmed-meshheading:17976125-Azathioprine, pubmed-meshheading:17976125-Biopsy, Needle, pubmed-meshheading:17976125-Child, pubmed-meshheading:17976125-Child, Preschool, pubmed-meshheading:17976125-Cyclosporine, pubmed-meshheading:17976125-Drug Therapy, Combination, pubmed-meshheading:17976125-Female, pubmed-meshheading:17976125-Follow-Up Studies, pubmed-meshheading:17976125-Glucocorticoids, pubmed-meshheading:17976125-Graft Rejection, pubmed-meshheading:17976125-Graft Survival, pubmed-meshheading:17976125-Humans, pubmed-meshheading:17976125-Immunosuppressive Agents, pubmed-meshheading:17976125-Infant, pubmed-meshheading:17976125-Kidney Failure, Chronic, pubmed-meshheading:17976125-Kidney Transplantation, pubmed-meshheading:17976125-Male, pubmed-meshheading:17976125-Methylprednisolone, pubmed-meshheading:17976125-Prospective Studies, pubmed-meshheading:17976125-Risk Factors, pubmed-meshheading:17976125-Survival Rate, pubmed-meshheading:17976125-Time Factors, pubmed-meshheading:17976125-Treatment Outcome
pubmed:year
2007
pubmed:articleTitle
Early treatment of acute rejections gives favorable long-term function after renal transplantation in small children.
pubmed:affiliation
Hospital for Children and Adolescents, Pediatric Nephrology and Transplantation, University of Helsinki, Helsinki, Finland. erik.qvist@kolumbus.fi
pubmed:publicationType
Journal Article