Source:http://linkedlifedata.com/resource/pubmed/id/17966069
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
23
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pubmed:dateCreated |
2007-10-29
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pubmed:abstractText |
Lipid peroxidation, a major contributor to cellular damage, is also implicated in the pathogenesis of autoimmune diseases (AD). The focus of this study was to elucidate the role of lipid peroxidation-derived aldehydes in autoimmunity induced and/or exacerbated by chemical exposure. Previous studies showed that trichloroethene (TCE) is capable of inducing/accelerating autoimmunity. To test whether TCE-induced lipid peroxidation might be involved in the induction/exacerbation of autoimmune responses, groups of autoimmune-prone female MRL +/+ mice were treated with TCE (10 mmol/kg, i.p., every 4th day) for 6 or 12 wk. Significant increases of the formation of malondialdehyde (MDA)- and 4-hydroxynonenal (HNE)-protein adducts were found in the livers of TCE-treated mice at both 6 and 12 wk, but the response was greater at 12 wk. Further characterization of these adducts in liver microsomes showed increased formation of MDA-protein adducts with molecular masses of 86, 65, 56, 44, and 32 kD, and of HNE-protein adducts with molecular masses of 87, 79, 46, and 17 kD in TCE-treated mice. In addition, significant induction of anti-MDA- and anti-HNE-protein adduct-specific antibodies was observed in the sera of TCE-treated mice, and showed a pattern similar to MDA- or HNE-protein adducts. The increases in anti-MDA- and anti-HNE-protein adduct antibodies were associated with significant elevation in serum anti-nuclear-, anti-ssDNA- and anti-dsDNA-antibodies at 6 wk and, to a greater extent, at 12 wk. These studies suggest that TCE-induced lipid peroxidation is associated with induction/exacerbation of autoimmune response in MRL+/+ mice, and thus may play an important role in disease pathogenesis. Further interventional studies are needed to establish a causal relationship between lipid peroxidation and TCE-induced autoimmune response.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aldehydes,
http://linkedlifedata.com/resource/pubmed/chemical/Autoantibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Malondialdehyde,
http://linkedlifedata.com/resource/pubmed/chemical/Trichloroethylene,
http://linkedlifedata.com/resource/pubmed/chemical/tert-4-hydroxy-2-nonenal
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1528-7394
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
70
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1977-85
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pubmed:meshHeading |
pubmed-meshheading:17966069-Aldehydes,
pubmed-meshheading:17966069-Animals,
pubmed-meshheading:17966069-Autoantibodies,
pubmed-meshheading:17966069-Autoimmune Diseases,
pubmed-meshheading:17966069-Disease Models, Animal,
pubmed-meshheading:17966069-Female,
pubmed-meshheading:17966069-Lipid Peroxidation,
pubmed-meshheading:17966069-Malondialdehyde,
pubmed-meshheading:17966069-Mice,
pubmed-meshheading:17966069-Microsomes, Liver,
pubmed-meshheading:17966069-Trichloroethylene
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pubmed:year |
2007
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pubmed:articleTitle |
Involvement of lipid peroxidation-derived aldehyde-protein adducts in autoimmunity mediated by trichloroethene.
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pubmed:affiliation |
Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77555-0609, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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