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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-12-24
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pubmed:abstractText |
Sex steroids are important for growth and maintenance of the skeleton. Catechol-O-methyltransferase (COMT) is an estrogen degrading enzyme. The COMT val158met polymorphism results in a 60-75% difference in enzyme activity between the val (high activity=H) and met (low activity=L) variants. We have previously reported that this polymorphism is associated with bone mineral density (BMD) in young men. The aim of this study was to investigate associations between COMT val158met, BMD and fractures in elderly men.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
8756-3282
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
107-12
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pubmed:meshHeading |
pubmed-meshheading:17962094-Catechol O-Methyltransferase,
pubmed-meshheading:17962094-Fractures, Bone,
pubmed-meshheading:17962094-Genotype,
pubmed-meshheading:17962094-Humans,
pubmed-meshheading:17962094-Male,
pubmed-meshheading:17962094-Methionine,
pubmed-meshheading:17962094-Polymorphism, Genetic,
pubmed-meshheading:17962094-Risk Factors,
pubmed-meshheading:17962094-Sweden,
pubmed-meshheading:17962094-Valine
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pubmed:year |
2008
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pubmed:articleTitle |
The COMT val158met polymorphism is associated with prevalent fractures in Swedish men.
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pubmed:affiliation |
Center for Bone Research at the Sahlgrenska Academy, Departments of Internal Medicine and Geriatrics, The Sahlgrenska Academy at Göteborg University, Göteborg, Sweden. anna.eriksson@pharm.gu.se
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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