Linked Life Data

17960686

Source:http://linkedlifedata.com/resource/pubmed/id/17960686

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2007-10-25
pubmed:abstractText
The pathophysiologic mechanisms of migraine are complex but appear to primarily involve the trigeminovascular system. Within this system, a number of factors may contribute to the generation and perpetuation of pathophysiologic changes leading to migraine. Current migraine medications exert their therapeutic benefit via actions at various points relating to these pathophysiologic changes. However, no single agent currently exists that targets all the hypothesized anatomical and cellular mechanisms of the migraine process. A future strategy for achieving optimal therapeutic effect and improving clinical outcomes in migraine involves rational targeting of the multiple mechanisms involved in its pathophysiology; conceptually, this may require concomitant use of multiple pharmacotherapeutic agents.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0032-5481
pubmed:author
pubmed:issnType
Print
pubmed:volume
Spec No
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5-13
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
An update on migraine pathophysiology and mechanism-based pharmacotherapeutics for migraine.
pubmed:publicationType
Journal Article, Review