Linked Life Data

17954222

Source:http://linkedlifedata.com/resource/pubmed/id/17954222

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2007-10-23
pubmed:abstractText
Within the domain of lipidomics, lipid mediator lipidomics and informatics is an exciting area because of the important roles of lipid-derived mediators in health and disease. It is well-appreciated that arachidonic acid is a precursor to potent bioactive mediators, such as prostaglandins, leukotrienes, and lipoxins. Recent experiments employing a mediator-lipidomic approach have uncovered that other major essential polyunsaturated fatty acids, such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), serve as precursors for the production of potent bioactive mediator families, coined "resolvins" and "protectins." These omega-3 polyunsaturated fatty acids have long been noted to have beneficial effects in human systems; however, molecular evidence for their beneficial actions has been lacking and/or subject to debate. In this chapter, we review the databases and search algorithms used to identify these novel lipid mediators using liquid chromatography-ultraviolet-tandem mass spectrometry (LC-UV-MS/MS). Cognoscitive-contrast-angle algorithms and databases (COCAD) and systematic naming and empirical fragmentation rules useful in MS/MS ion identification were developed. Examples of identifying eicosanoids, resolvins, and protectins are given in human and murine tissues. The findings reviewed in this chapter demonstrate the advantages of COCAD in profiling and identification of bioactive lipid mediators and documenting activation of their biosynthetic pathways as well as in establishing relationships between lipid mediator pathways with agonists and antagonists present in the biological system.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0076-6879
pubmed:author
pubmed:issnType
Print
pubmed:volume
432
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
275-317
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Mediator lipidomics: search algorithms for eicosanoids, resolvins, and protectins.
pubmed:affiliation
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural