Linked Life Data

17952012

Source:http://linkedlifedata.com/resource/pubmed/id/17952012

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-1-25
pubmed:abstractText
The contractile activity of the novel 5-HT(3) receptor agonist MKC-733 was determined in intestinal tissues of rats, guinea pigs and mice. The potential influence of non-5-HT(3) receptors was removed by the inclusion of methysergide and GR125487. MKC-733 had a lower efficacy than 5-HT in the rat jejunum, ileum and distal colon; however, it had similar efficacy and potency to 5-HT in the rat proximal colon. The activity profile of MKC-733 was different in the guinea pig intestine where it exhibited greater potency and efficacy than 5-HT in all regions. MKC-733 showed little to no response in the regions of the mouse intestine. Responses to MKC-733 in the rat and guinea pig tissues were inhibited by ondansetron, confirming its action on 5-HT(3) receptors. These in vitro studies indicate that MKC-733 displays both regional and species specificities.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1423-0313
pubmed:author
pubmed:copyrightInfo
(c) 2008 S. Karger AG, Basel.
pubmed:issnType
Electronic
pubmed:volume
81
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
104-9
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Effects of the novel 5-HT3 agonist MKC-733 on the rat, mouse and guinea pig digestive tract.
pubmed:affiliation
Department of Pharmaceutical Biology, Victorian College of Pharmacy, Monash University, Parkville, Australia.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't