Source:http://linkedlifedata.com/resource/pubmed/id/17949929
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2007-12-6
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| pubmed:abstractText |
Taraxacum officinale has been widely used as a folkloric medicine for the treatment of diverse diseases. The dried plant was extracted with 70% ethanol to generate its ethanol extract (TEE). For some experiments, ethyl acetate (EA), n-butanol (BuOH) and aqueous (Aq) fractions were prepared in succession from TEE. TEE showed a scavenging activity in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay, a diminishing effect on intracellular reactive oxygen species (ROS) level, and an anti-angiogenic activity in the chicken chorioallantoic (CAM) assay. In the carrageenan-induced air pouch model, TEE inhibited production of exudate, and significantly diminished nitric oxide (NO) and leukocyte levels in the exudate. It also possessed an inhibitory effect on acetic acid-induced vascular permeability and caused a dose-dependent inhibition on acetic acid-induced abdominal writhing in mice. Suppressive effects of TEE on the production of NO and expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-stimulated macrophages were also assessed. Among the fractions, the n-butanol fraction (BuOH) was identified to be most effective in the CAM assay. Collectively, Taraxacum officinale contains anti-angiogenic, anti-inflammatory and anti-nociceptive activities through its inhibition of NO production and COX-2 expression and/or its antioxidative activity.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiogenesis Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Free Radicals,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Extracts,
http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
0378-8741
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
4
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| pubmed:volume |
115
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
82-8
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| pubmed:meshHeading |
pubmed-meshheading:17949929-Angiogenesis Inhibitors,
pubmed-meshheading:17949929-Animals,
pubmed-meshheading:17949929-Anti-Inflammatory Agents,
pubmed-meshheading:17949929-Antioxidants,
pubmed-meshheading:17949929-Chick Embryo,
pubmed-meshheading:17949929-Chorioallantoic Membrane,
pubmed-meshheading:17949929-Dose-Response Relationship, Drug,
pubmed-meshheading:17949929-Free Radicals,
pubmed-meshheading:17949929-Leukocytes,
pubmed-meshheading:17949929-Male,
pubmed-meshheading:17949929-Medicine, Traditional,
pubmed-meshheading:17949929-Mice,
pubmed-meshheading:17949929-Mice, Inbred ICR,
pubmed-meshheading:17949929-Nitric Oxide,
pubmed-meshheading:17949929-Pain,
pubmed-meshheading:17949929-Plant Extracts,
pubmed-meshheading:17949929-Rats,
pubmed-meshheading:17949929-Rats, Sprague-Dawley,
pubmed-meshheading:17949929-Reactive Oxygen Species,
pubmed-meshheading:17949929-Taraxacum
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| pubmed:year |
2008
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| pubmed:articleTitle |
Anti-inflammatory activity of Taraxacum officinale.
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| pubmed:affiliation |
College of Pharmacy, Sookmyung Women's University, Cheongpa-dong, Yongsan-ku, Seoul 140-742, Republic of Korea.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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