| pubmed-article:17942935 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17942935 | lifeskim:mentions | umls-concept:C0006826 | lld:lifeskim |
| pubmed-article:17942935 | lifeskim:mentions | umls-concept:C0025260 | lld:lifeskim |
| pubmed-article:17942935 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:17942935 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:17942935 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:17942935 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:17942935 | lifeskim:mentions | umls-concept:C0020964 | lld:lifeskim |
| pubmed-article:17942935 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:17942935 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:17942935 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:17942935 | lifeskim:mentions | umls-concept:C1317973 | lld:lifeskim |
| pubmed-article:17942935 | lifeskim:mentions | umls-concept:C0183683 | lld:lifeskim |
| pubmed-article:17942935 | lifeskim:mentions | umls-concept:C0344211 | lld:lifeskim |
| pubmed-article:17942935 | lifeskim:mentions | umls-concept:C1521721 | lld:lifeskim |
| pubmed-article:17942935 | lifeskim:mentions | umls-concept:C0302350 | lld:lifeskim |
| pubmed-article:17942935 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:17942935 | lifeskim:mentions | umls-concept:C1171411 | lld:lifeskim |
| pubmed-article:17942935 | pubmed:issue | 20 | lld:pubmed |
| pubmed-article:17942935 | pubmed:dateCreated | 2007-10-18 | lld:pubmed |
| pubmed-article:17942935 | pubmed:abstractText | In contrast to the well-established efficacy of preventive vaccines, the effectiveness of therapeutic vaccines remains limited. To develop effective vaccination regimens against cancer, we have analyzed the effect of effector and memory CD8+ T cells on the ability of dendritic cells to mediate the immunologic and antitumor effects of vaccination. We show that in contrast to effector CD8+ T cells that kill antigen-carrying dendritic cells, IFNgamma-producing memory CD8+ T cells act as "helper" cells, supporting the ability of dendritic cells to produce interleukin-12 (IL-12) p70. Promoting the interaction of tumor antigen-carrying dendritic cells with memory-type "heterologous" (tumor-irrelevant) CD8+ T cells strongly enhances the IL-12p70-dependent immunogenic and therapeutic effects of vaccination in the animals bearing established tumors. Our data show that the suppressive and helper functions of CD8+ T cells are differentially expressed at different phases of CD8+ T-cell responses. Selective performance of helper functions by memory (in contrast to effector) CD8+ T cells helps to explain the phenomenon of immune memory and facilitates the design of effective therapeutic vaccines against cancer and chronic infections. | lld:pubmed |
| pubmed-article:17942935 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17942935 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17942935 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17942935 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17942935 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17942935 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17942935 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17942935 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17942935 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17942935 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17942935 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17942935 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17942935 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17942935 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17942935 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17942935 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17942935 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17942935 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17942935 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17942935 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17942935 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17942935 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17942935 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17942935 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17942935 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17942935 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17942935 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17942935 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17942935 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17942935 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17942935 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17942935 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17942935 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17942935 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17942935 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17942935 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17942935 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17942935 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17942935 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17942935 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17942935 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17942935 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17942935 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17942935 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17942935 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17942935 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17942935 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:17942935 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:17942935 | pubmed:author | pubmed-author:GiermaszAdamA | lld:pubmed |
| pubmed-article:17942935 | pubmed:author | pubmed-author:KalinskiPawel... | lld:pubmed |
| pubmed-article:17942935 | pubmed:author | pubmed-author:StorkusWalter... | lld:pubmed |
| pubmed-article:17942935 | pubmed:author | pubmed-author:MailliardRobb... | lld:pubmed |
| pubmed-article:17942935 | pubmed:author | pubmed-author:GoodingWillia... | lld:pubmed |
| pubmed-article:17942935 | pubmed:author | pubmed-author:LarreginaAdri... | lld:pubmed |
| pubmed-article:17942935 | pubmed:author | pubmed-author:NakamuraYutar... | lld:pubmed |
| pubmed-article:17942935 | pubmed:author | pubmed-author:OkadaHidehoH | lld:pubmed |
| pubmed-article:17942935 | pubmed:author | pubmed-author:CumberlandRac... | lld:pubmed |
| pubmed-article:17942935 | pubmed:author | pubmed-author:SheridanBrian... | lld:pubmed |
| pubmed-article:17942935 | pubmed:author | pubmed-author:HendricksRobe... | lld:pubmed |
| pubmed-article:17942935 | pubmed:author | pubmed-author:NishimuraFumi... | lld:pubmed |
| pubmed-article:17942935 | pubmed:author | pubmed-author:SasakiKotaroK | lld:pubmed |
| pubmed-article:17942935 | pubmed:author | pubmed-author:FaloLouis DLD | lld:pubmed |
| pubmed-article:17942935 | pubmed:author | pubmed-author:RavikumarMuth... | lld:pubmed |
| pubmed-article:17942935 | pubmed:author | pubmed-author:WatchmakerPay... | lld:pubmed |
| pubmed-article:17942935 | pubmed:author | pubmed-author:UrbanJulieJ | lld:pubmed |
| pubmed-article:17942935 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17942935 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:17942935 | pubmed:volume | 67 | lld:pubmed |
| pubmed-article:17942935 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17942935 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17942935 | pubmed:pagination | 10012-8 | lld:pubmed |
| pubmed-article:17942935 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
| pubmed-article:17942935 | pubmed:meshHeading | pubmed-meshheading:17942935... | lld:pubmed |
| pubmed-article:17942935 | pubmed:meshHeading | pubmed-meshheading:17942935... | lld:pubmed |
| pubmed-article:17942935 | pubmed:meshHeading | pubmed-meshheading:17942935... | lld:pubmed |
| pubmed-article:17942935 | pubmed:meshHeading | pubmed-meshheading:17942935... | lld:pubmed |
| pubmed-article:17942935 | pubmed:meshHeading | pubmed-meshheading:17942935... | lld:pubmed |
| pubmed-article:17942935 | pubmed:meshHeading | pubmed-meshheading:17942935... | lld:pubmed |
| pubmed-article:17942935 | pubmed:meshHeading | pubmed-meshheading:17942935... | lld:pubmed |
