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rdf:type |
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lifeskim:mentions |
umls-concept:C0006826,
umls-concept:C0020964,
umls-concept:C0025260,
umls-concept:C0039194,
umls-concept:C0085358,
umls-concept:C0183683,
umls-concept:C0205263,
umls-concept:C0302350,
umls-concept:C0344211,
umls-concept:C0542341,
umls-concept:C1171411,
umls-concept:C1317973,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1521721,
umls-concept:C1706438,
umls-concept:C2698600
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pubmed:issue |
20
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pubmed:dateCreated |
2007-10-18
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pubmed:abstractText |
In contrast to the well-established efficacy of preventive vaccines, the effectiveness of therapeutic vaccines remains limited. To develop effective vaccination regimens against cancer, we have analyzed the effect of effector and memory CD8+ T cells on the ability of dendritic cells to mediate the immunologic and antitumor effects of vaccination. We show that in contrast to effector CD8+ T cells that kill antigen-carrying dendritic cells, IFNgamma-producing memory CD8+ T cells act as "helper" cells, supporting the ability of dendritic cells to produce interleukin-12 (IL-12) p70. Promoting the interaction of tumor antigen-carrying dendritic cells with memory-type "heterologous" (tumor-irrelevant) CD8+ T cells strongly enhances the IL-12p70-dependent immunogenic and therapeutic effects of vaccination in the animals bearing established tumors. Our data show that the suppressive and helper functions of CD8+ T cells are differentially expressed at different phases of CD8+ T-cell responses. Selective performance of helper functions by memory (in contrast to effector) CD8+ T cells helps to explain the phenomenon of immune memory and facilitates the design of effective therapeutic vaccines against cancer and chronic infections.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17942935-10377183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17942935-10706699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17942935-10878366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17942935-10925267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17942935-10993913,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17942935-11535633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17942935-11535638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17942935-11751965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17942935-11854360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17942935-11861612,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17942935-11983228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17942935-12001996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17942935-12563297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17942935-12594515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17942935-12705853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17942935-12827303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17942935-12909449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17942935-14069243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17942935-1419956,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17942935-15102369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17942935-15314520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17942935-15340416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17942935-15688371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17942935-15951824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17942935-16373503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17942935-16464565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17942935-16515492,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17942935-16751382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17942935-4401006,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17942935-6457682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17942935-8235039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17942935-8760829,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17942935-8837611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17942935-9624003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17942935-9624004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17942935-9624005
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0008-5472
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pubmed:author |
pubmed-author:CumberlandRachelR,
pubmed-author:FaloLouis DLD,
pubmed-author:GiermaszAdamA,
pubmed-author:GoodingWilliamW,
pubmed-author:HendricksRobert LRL,
pubmed-author:KalinskiPawelP,
pubmed-author:LarreginaAdriana TAT,
pubmed-author:MailliardRobbie BRB,
pubmed-author:NakamuraYutaroY,
pubmed-author:NishimuraFumihikoF,
pubmed-author:OkadaHidehoH,
pubmed-author:RavikumarMuthuswamyM,
pubmed-author:SasakiKotaroK,
pubmed-author:SheridanBrianB,
pubmed-author:StorkusWalter JWJ,
pubmed-author:UrbanJulieJ,
pubmed-author:WatchmakerPayalP
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
10012-8
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
|
