Linked Life Data

17936367

Source:http://linkedlifedata.com/resource/pubmed/id/17936367

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2008-1-14
pubmed:abstractText
Environmental light entrains activity of the suprachiasmatic nucleus (SCN), the mammalian circadian pacemaker. Using Fos as marker of neuronal activation, we investigated whether chronic systemic endotoxin administration can alter SCN responsiveness to light after different time intervals. Mice were treated i.p. with lipopolysaccharide for 60 days, and exposed to photic stimulation 7 or 30 days later. Light-induced Fos immunosignal in the SCN was highly significantly decreased versus controls at 7 days, and returned to control levels at 30 days. The data show that SCN function is altered by chronic inflammation and that this effect is reversible over time.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0165-5728
pubmed:author
pubmed:issnType
Print
pubmed:volume
193
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
24-7
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Chronic inflammation affects the photic response of the suprachiasmatic nucleus.
pubmed:affiliation
Department of Morphological and Biomedical Sciences, University of Verona, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't