Source:http://linkedlifedata.com/resource/pubmed/id/17928436
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
41
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pubmed:dateCreated |
2007-10-11
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pubmed:abstractText |
The AMPA receptor subunit glutamate receptor 1 (GluR1 or GluR-A) contributes to amygdala-dependent emotional learning. It remains unclear, however, to what extent different amygdala pathways depend on GluR1, or other AMPA receptor subunits, for proper synaptic transmission and plasticity, and whether GluR1-dependent long-term potentiation (LTP) is necessary for auditory and contextual fear conditioning. Here, we dissected the role of GluR1 and GluR3 (GluR-C) subunits in AMPA receptor-dependent amygdala LTP and fear conditioning using knock-out mice (GluR1-/- and GluR3-/-). We found that, whereas LTP at thalamic inputs to lateral amygdala (LA) projection neurons and at glutamatergic synapses in the basal amygdala was completely absent in GluR1-/- mice, both GluR1 and GluR3 contributed to LTP in the cortico-LA pathway. Because both auditory and contextual fear conditioning were selectively impaired in GluR1-/- but not GluR3-/- mice, we conclude that GluR1-dependent synaptic plasticity is the dominant form of LTP underlying the acquisition of auditory and contextual fear conditioning, and that plasticity in distinct amygdala pathways differentially contributes to aversive conditioning.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1529-2401
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pubmed:author |
pubmed-author:BannermanDavid MDM,
pubmed-author:BorchardtThiloT,
pubmed-author:GassPeterP,
pubmed-author:GebhardtChristineC,
pubmed-author:GoodMark AMA,
pubmed-author:HumeauYannY,
pubmed-author:HvalbyØivindØ,
pubmed-author:JensenVidarV,
pubmed-author:JohnsonAlexander WAW,
pubmed-author:LüthiAndreasA,
pubmed-author:LiaoMei-linML,
pubmed-author:ReiselDanielD,
pubmed-author:SprengelRolfR
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pubmed:issnType |
Electronic
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pubmed:day |
10
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
10947-56
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pubmed:meshHeading |
pubmed-meshheading:17928436-Amygdala,
pubmed-meshheading:17928436-Animals,
pubmed-meshheading:17928436-Conditioning (Psychology),
pubmed-meshheading:17928436-Fear,
pubmed-meshheading:17928436-Long-Term Potentiation,
pubmed-meshheading:17928436-Male,
pubmed-meshheading:17928436-Mice,
pubmed-meshheading:17928436-Mice, Inbred C57BL,
pubmed-meshheading:17928436-Mice, Knockout,
pubmed-meshheading:17928436-Neural Pathways,
pubmed-meshheading:17928436-Protein Subunits,
pubmed-meshheading:17928436-Receptors, AMPA
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pubmed:year |
2007
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pubmed:articleTitle |
A pathway-specific function for different AMPA receptor subunits in amygdala long-term potentiation and fear conditioning.
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pubmed:affiliation |
Friedrich Miescher Institute for Biomedical Research, CH-4058 Basel, Switzerland.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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