Neurotoxicity related to the Abeta peptide is thought to be a primary mechanism of dysfunction in Alzheimer disease (AD). Although numerous imaging studies have observed brain dysfunction in AD, whether these imaged defects reflect Abeta-related neurotoxicity remains unknown.
Department of Neurology, Robert S. Furchgott Center for Neural and Behavioral Sciences, State University of New York, Downstate Medical Center, Brooklyn, NY, USA.