Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2008-3-10
pubmed:abstractText
There is ongoing debate concerning whether new protein synthesis is necessary for, or even contributes to, memory formation and storage. This review summarizes a contemporary model proposing a role for altered protein synthesis in memory formation and its subsequent stabilization. One defining aspect of the model is that altered protein synthesis serves as a trigger for memory consolidation. Thus, we propose that specific alterations in the pattern of neuronal protein translation serve as an initial event in long-term memory formation. These specific alterations in protein readout result in the formation of a protein complex that then serves as a nidus for subsequent perpetuating reinforcement by a positive feedback mechanism. The model proposes this scenario as a minimal but requisite component for long-term memory formation. Our description specifies three aspects of prevailing scenarios for the role of altered protein synthesis in memory that we feel will help clarify what, precisely, is typically proposed as the role for protein translation in memory formation. First, that a relatively short initial time window exists wherein specific alterations in the pattern of proteins translated (not overall protein synthesis) is involved in initializing the engram. Second, that a self-perpetuating positive feedback mechanism maintains the altered pattern of protein expression (synthesis or recruitment) locally. Third, that other than the formation and subsequent perpetuation of the unique initializing proteins, ongoing constitutive protein synthesis is all that is minimally necessary for formation and maintenance of the engram. We feel that a clear delineation of these three principles will assist in interpreting the available experimental data, and propose that the available data are consistent with a role for protein synthesis in memory.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-10509708, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-10872469, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-11106749, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-11283313, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-11297505, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-11701324, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-11756682, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-12150925, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-12581660, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-12665511, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-12747827, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-12820960, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-12912989, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-12925020, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-12925279, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-15016380, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-15066126, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-15277680, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-15314020, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-15450160, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-15550948, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-15624019, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-15626492, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-15652868, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-15705855, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-15755954, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-15958750, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-16121183, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-16237163, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-16791146, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-16885218, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-16931766, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-17005423, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-17015847, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-17167087, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-17351144, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-17392460, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-17418795, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-17537959, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-217002, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-2627380, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-3967293, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-4504352, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-4918323, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-5955961, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-7935836, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-8521521, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-8942955, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-8971030, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-9454331, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-9767396, http://linkedlifedata.com/resource/pubmed/commentcorrection/17919940-9857202
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Anisomycin, http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Eif2ak4 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Eif4ebp1 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Eukaryotic Initiation Factor-2, http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins, http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Protein Synthesis Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate, http://linkedlifedata.com/resource/pubmed/chemical/Ribosomal Protein S6 Kinases, 70-kDa, http://linkedlifedata.com/resource/pubmed/chemical/TOR Serine-Threonine Kinases, http://linkedlifedata.com/resource/pubmed/chemical/mTOR protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/ribosomal protein S6 kinase, 70kD...
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1095-9564
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
89
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
247-59
pubmed:dateRevised
2011-5-30
pubmed:meshHeading
More...