| pubmed-article:17916350 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17916350 | lifeskim:mentions | umls-concept:C0002771 | lld:lifeskim |
| pubmed-article:17916350 | lifeskim:mentions | umls-concept:C0003209 | lld:lifeskim |
| pubmed-article:17916350 | lifeskim:mentions | umls-concept:C0387583 | lld:lifeskim |
| pubmed-article:17916350 | lifeskim:mentions | umls-concept:C1533698 | lld:lifeskim |
| pubmed-article:17916350 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:17916350 | lifeskim:mentions | umls-concept:C1515999 | lld:lifeskim |
| pubmed-article:17916350 | lifeskim:mentions | umls-concept:C0205296 | lld:lifeskim |
| pubmed-article:17916350 | lifeskim:mentions | umls-concept:C0619195 | lld:lifeskim |
| pubmed-article:17916350 | lifeskim:mentions | umls-concept:C0205198 | lld:lifeskim |
| pubmed-article:17916350 | lifeskim:mentions | umls-concept:C1009004 | lld:lifeskim |
| pubmed-article:17916350 | lifeskim:mentions | umls-concept:C1038069 | lld:lifeskim |
| pubmed-article:17916350 | pubmed:issue | 2-3 | lld:pubmed |
| pubmed-article:17916350 | pubmed:dateCreated | 2008-1-1 | lld:pubmed |
| pubmed-article:17916350 | pubmed:abstractText | Lemnalol (8-isopropyl-5-methyl-4-methylene-decahydro-1,5-cyclo-naphthalen-3-ol) is a natural compound isolated from the marine soft coral Lemnalia cervicorni. In the present study, the anti-inflammatory and anti-nociceptive properties of lemnalol were investigated in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and carrageenan-injected rats, respectively. Our results demonstrate that lemnalol significantly inhibited the expression of the pro-inflammatory proteins, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), in LPS-stimulated RAW 264.7 cells. An in vivo inflammation model was induced by intraplantar injection of carrageenan into rat hind paws. An intramuscular injection of lemnalol (15 mg/kg) 10 min before carrageenan injection resulted in significant inhibition of carrageenan-induced rat paw edema and thermal hyperalgesia behavior. Western blot experiments revealed that the carrageenan-induced expression of iNOS and COX-2 in paw tissue was significantly down-regulated by lemnalol. Moreover, post-intrathecal injection of lemnalol produced a dose-dependent anti-nociceptive effect in carrageenan-injected rats (1 and 5 microg). The present results indicate that the marine-derived compound lemnalol had anti-inflammatory and analgesic effects in LPS-stimulated RAW 264.7 cells and carrageenan-injected rats, respectively. In addition, inhibition of elevated iNOS and COX-2 protein expression as well as neurophil infiltration of carrageenan-injected paws may be involved in the beneficial effects of lemnalol. | lld:pubmed |
| pubmed-article:17916350 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17916350 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17916350 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17916350 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17916350 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17916350 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17916350 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:17916350 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:17916350 | pubmed:author | pubmed-author:WenZhi-HongZH | lld:pubmed |
| pubmed-article:17916350 | pubmed:author | pubmed-author:LinChan-Shing... | lld:pubmed |
| pubmed-article:17916350 | pubmed:author | pubmed-author:ChenI-MingIM | lld:pubmed |
| pubmed-article:17916350 | pubmed:author | pubmed-author:SungChun-Sung... | lld:pubmed |
| pubmed-article:17916350 | pubmed:author | pubmed-author:HuangShi-Ying... | lld:pubmed |
| pubmed-article:17916350 | pubmed:author | pubmed-author:ChenWu-FuWF | lld:pubmed |
| pubmed-article:17916350 | pubmed:author | pubmed-author:JeanYen-Hsuan... | lld:pubmed |
| pubmed-article:17916350 | pubmed:author | pubmed-author:HsuChi-HsinCH | lld:pubmed |
| pubmed-article:17916350 | pubmed:author | pubmed-author:DuhChang-YiCY | lld:pubmed |
| pubmed-article:17916350 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17916350 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:17916350 | pubmed:volume | 578 | lld:pubmed |
| pubmed-article:17916350 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17916350 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17916350 | pubmed:pagination | 323-31 | lld:pubmed |
| pubmed-article:17916350 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:17916350 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:17916350 | pubmed:articleTitle | Inducible nitric oxide synthase and cyclooxygenase-2 participate in anti-inflammatory and analgesic effects of the natural marine compound lemnalol from Formosan soft coral Lemnalia cervicorni. | lld:pubmed |
| pubmed-article:17916350 | pubmed:affiliation | Section of Orthopedic Surgery, Pingtung Christian Hospital, #60 Da-Lan Road, Pingtung 900, Taiwan. | lld:pubmed |
| pubmed-article:17916350 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17916350 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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