Linked Life Data

17916350

Source:http://linkedlifedata.com/resource/pubmed/id/17916350

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
2008-1-1
pubmed:abstractText
Lemnalol (8-isopropyl-5-methyl-4-methylene-decahydro-1,5-cyclo-naphthalen-3-ol) is a natural compound isolated from the marine soft coral Lemnalia cervicorni. In the present study, the anti-inflammatory and anti-nociceptive properties of lemnalol were investigated in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and carrageenan-injected rats, respectively. Our results demonstrate that lemnalol significantly inhibited the expression of the pro-inflammatory proteins, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), in LPS-stimulated RAW 264.7 cells. An in vivo inflammation model was induced by intraplantar injection of carrageenan into rat hind paws. An intramuscular injection of lemnalol (15 mg/kg) 10 min before carrageenan injection resulted in significant inhibition of carrageenan-induced rat paw edema and thermal hyperalgesia behavior. Western blot experiments revealed that the carrageenan-induced expression of iNOS and COX-2 in paw tissue was significantly down-regulated by lemnalol. Moreover, post-intrathecal injection of lemnalol produced a dose-dependent anti-nociceptive effect in carrageenan-injected rats (1 and 5 microg). The present results indicate that the marine-derived compound lemnalol had anti-inflammatory and analgesic effects in LPS-stimulated RAW 264.7 cells and carrageenan-injected rats, respectively. In addition, inhibition of elevated iNOS and COX-2 protein expression as well as neurophil infiltration of carrageenan-injected paws may be involved in the beneficial effects of lemnalol.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
14
pubmed:volume
578
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
323-31
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:17916350-Analgesics, pubmed-meshheading:17916350-Animals, pubmed-meshheading:17916350-Anthozoa, pubmed-meshheading:17916350-Anti-Inflammatory Agents, pubmed-meshheading:17916350-Carrageenan, pubmed-meshheading:17916350-Cell Line, pubmed-meshheading:17916350-Cyclooxygenase 2, pubmed-meshheading:17916350-Disease Models, Animal, pubmed-meshheading:17916350-Dose-Response Relationship, Drug, pubmed-meshheading:17916350-Hot Temperature, pubmed-meshheading:17916350-Hyperalgesia, pubmed-meshheading:17916350-Immunohistochemistry, pubmed-meshheading:17916350-Inflammation, pubmed-meshheading:17916350-Injections, Spinal, pubmed-meshheading:17916350-Lipopolysaccharides, pubmed-meshheading:17916350-Macrophages, pubmed-meshheading:17916350-Male, pubmed-meshheading:17916350-Mice, pubmed-meshheading:17916350-Neutrophil Infiltration, pubmed-meshheading:17916350-Nitric Oxide Synthase Type II, pubmed-meshheading:17916350-Pain Measurement, pubmed-meshheading:17916350-Pain Threshold, pubmed-meshheading:17916350-Rats, pubmed-meshheading:17916350-Rats, Wistar, pubmed-meshheading:17916350-Sesquiterpenes, pubmed-meshheading:17916350-Time Factors
pubmed:year
2008
pubmed:articleTitle
Inducible nitric oxide synthase and cyclooxygenase-2 participate in anti-inflammatory and analgesic effects of the natural marine compound lemnalol from Formosan soft coral Lemnalia cervicorni.
pubmed:affiliation
Section of Orthopedic Surgery, Pingtung Christian Hospital, #60 Da-Lan Road, Pingtung 900, Taiwan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't