Linked Life Data

17907430

Source:http://linkedlifedata.com/resource/pubmed/id/17907430

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2007-10-2
pubmed:abstractText
It is difficult to study the deformation of articular cartilage because it is an inhomogenous material with depth dependent constituents. In many experimental studies, cartilage is assumed to behave homogeneously and is subjected to only static or quasi-static loads. In this study, a thick walled, mechanically active culture device (TRIAX) was used to apply cyclic loading to cartilage explants at physiological stress levels. An arthroscope was fitted into the wall of the TRIAX to monitorand record the cyclic compressive behavior of the cartilage and to measure depth dependent cartilage strains. A common concern with arthroscopy systems is that the images obtained are radially distorted about a central point ("fisheye" view); therefore it is necessary to correct this distortion in order to accurately quantify distances between objects within the images. To do this, an algorithm was developed which used a calibration pattern to create an image transform. Digital video of the cyclic cartilage compression was recorded, and the distortion algorithm was applied to the images to measure the cartilage as it deformed. This technique will provide valuable and practical insight into cartilage mechanics and viability (via calcein AM-stained chondrocytes) during multiday cyclic loading of living cartilage explants. The implementation of an arthroscopy system provides the advantage of bringing microscope-level resolution into a cartilage compression device to allow for digital visualization of the entire explant at the whole-tissue level.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17907430-10342624, http://linkedlifedata.com/resource/pubmed/commentcorrection/17907430-10385291, http://linkedlifedata.com/resource/pubmed/commentcorrection/17907430-11285374, http://linkedlifedata.com/resource/pubmed/commentcorrection/17907430-11425068, http://linkedlifedata.com/resource/pubmed/commentcorrection/17907430-11465467, http://linkedlifedata.com/resource/pubmed/commentcorrection/17907430-12405599, http://linkedlifedata.com/resource/pubmed/commentcorrection/17907430-12588036, http://linkedlifedata.com/resource/pubmed/commentcorrection/17907430-12751279, http://linkedlifedata.com/resource/pubmed/commentcorrection/17907430-15046998, http://linkedlifedata.com/resource/pubmed/commentcorrection/17907430-15299249, http://linkedlifedata.com/resource/pubmed/commentcorrection/17907430-15678528, http://linkedlifedata.com/resource/pubmed/commentcorrection/17907430-16813454, http://linkedlifedata.com/resource/pubmed/commentcorrection/17907430-8841725, http://linkedlifedata.com/resource/pubmed/commentcorrection/17907430-9119822, http://linkedlifedata.com/resource/pubmed/commentcorrection/17907430-9184894, http://linkedlifedata.com/resource/pubmed/commentcorrection/17907430-9379258
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1541-5457
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
52-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Arthroscopic lens distortion correction applied to dynamic cartilage loading.
pubmed:affiliation
Department of Orthopaedics and Rehabilitation, The University of Iowa, Iowa City, IA 52242, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural