Source:http://linkedlifedata.com/resource/pubmed/id/17905650
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
10
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pubmed:dateCreated |
2007-10-8
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pubmed:abstractText |
Mice lacking I-FABP (encoded by the Fabp2 gene) exhibit a gender dimorphic response to a high fat/cholesterol diet challenge characterized by hepatomegaly in male I-FABP-deficient mice. In this study, we determined if this gender-specific modification of liver mass in mice lacking I-FABP is attributable to the high fat content of the diet alone and whether hepatic Fabp1 gene (encodes L-FABP) expression contributes to this difference. Wild-type and Fabp2-/- mice of both genders were fed a diet enriched with either polyunsaturated or saturated fatty acids (PUFA or SFA, respectively) in the absence of cholesterol. Male Fabp2-/- mice, but not female Fabp2-/- mice, exhibited increased liver mass and hepatic triacylglycerol (TG) deposition as compared to corresponding wild-type mice. In wild-type mice that were fed the standard chow diet, there was no difference in the concentration of hepatic L-FABP protein between males and females although the loss of I-FABP did cause a slight reduction of hepatic L-FABP abundance in both genders. The hepatic L-FABP mRNA abundance in both male and female wild-type and Fabp2-/- mice was higher in the PUFA-fed group than in the SFA-fed group, and was correlated with L-FABP protein abundance. No correlation between hepatic L-FABP protein abundance and hepatic TG concentration was found. The results obtained demonstrate that loss of I-FABP renders male mice sensitive to high fat diet-induced fatty liver, and this effect is independent of hepatic L-FABP.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0006-3002
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
1771
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1283-8
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pubmed:meshHeading |
pubmed-meshheading:17905650-Animals,
pubmed-meshheading:17905650-Body Weight,
pubmed-meshheading:17905650-Fatty Acid-Binding Proteins,
pubmed-meshheading:17905650-Fatty Liver,
pubmed-meshheading:17905650-Female,
pubmed-meshheading:17905650-Intestine, Small,
pubmed-meshheading:17905650-Lipids,
pubmed-meshheading:17905650-Liver,
pubmed-meshheading:17905650-Male,
pubmed-meshheading:17905650-Mice,
pubmed-meshheading:17905650-Mice, Inbred C57BL,
pubmed-meshheading:17905650-Mice, Transgenic,
pubmed-meshheading:17905650-RNA, Messenger,
pubmed-meshheading:17905650-Sex Factors,
pubmed-meshheading:17905650-Triglycerides
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pubmed:year |
2007
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pubmed:articleTitle |
Loss of intestinal fatty acid binding protein increases the susceptibility of male mice to high fat diet-induced fatty liver.
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pubmed:affiliation |
Canadian Institutes of Health Research Molecular and Cell Biology of Lipids Research Group and Department of Biochemistry, University of Alberta, Edmonton, AB, Canada T6G 2S2. luis.agellon@mcgill.ca
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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