| pubmed-article:17895593 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17895593 | lifeskim:mentions | umls-concept:C0008865 | lld:lifeskim |
| pubmed-article:17895593 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:17895593 | lifeskim:mentions | umls-concept:C0027746 | lld:lifeskim |
| pubmed-article:17895593 | lifeskim:mentions | umls-concept:C0233794 | lld:lifeskim |
| pubmed-article:17895593 | lifeskim:mentions | umls-concept:C0596577 | lld:lifeskim |
| pubmed-article:17895593 | lifeskim:mentions | umls-concept:C0332161 | lld:lifeskim |
| pubmed-article:17895593 | lifeskim:mentions | umls-concept:C0599668 | lld:lifeskim |
| pubmed-article:17895593 | lifeskim:mentions | umls-concept:C0062638 | lld:lifeskim |
| pubmed-article:17895593 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17895593 | pubmed:dateCreated | 2007-9-26 | lld:pubmed |
| pubmed-article:17895593 | pubmed:abstractText | We have recently reported that nobiletin, a citrus flavonoid, improves impaired memory in olfactory-bulbectomized (OBX) mice, which have been widely utilized as a useful paradigm that shares some major clinical features of Alzheimer's disease. Here, we examined the effects of nobiletin on OBX-induced cholinergic neurodegeneration in mice. OBX mice showed reduced acetylcholinesterase (AChE) staining and choline acetyltransferase (ChAT) expression in the hippocampus. An 11-day administration of nobiletin rescued OBX-induced decrease in the density of AChE-staining and ChAT expression in the hippocampus. These results suggest that nobiletin rescues OBX-induced cholinergic neurodegeneration, accompanied by improvement of impaired memory in OBX mice. | lld:pubmed |
| pubmed-article:17895593 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17895593 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17895593 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17895593 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17895593 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17895593 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17895593 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17895593 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17895593 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17895593 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17895593 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:17895593 | pubmed:issn | 1347-8613 | lld:pubmed |
| pubmed-article:17895593 | pubmed:author | pubmed-author:OhizumiYasush... | lld:pubmed |
| pubmed-article:17895593 | pubmed:author | pubmed-author:MimakiYoshihi... | lld:pubmed |
| pubmed-article:17895593 | pubmed:author | pubmed-author:SashidaYutaka... | lld:pubmed |
| pubmed-article:17895593 | pubmed:author | pubmed-author:YokosukaAkihi... | lld:pubmed |
| pubmed-article:17895593 | pubmed:author | pubmed-author:TadanoTakeshi... | lld:pubmed |
| pubmed-article:17895593 | pubmed:author | pubmed-author:KatoChiekoC | lld:pubmed |
| pubmed-article:17895593 | pubmed:author | pubmed-author:SongSi-YoungS... | lld:pubmed |
| pubmed-article:17895593 | pubmed:author | pubmed-author:NakajimaAkira... | lld:pubmed |
| pubmed-article:17895593 | pubmed:author | pubmed-author:YamakuniTohru... | lld:pubmed |
| pubmed-article:17895593 | pubmed:author | pubmed-author:NakagawasaiOs... | lld:pubmed |
| pubmed-article:17895593 | pubmed:author | pubmed-author:OmaeNaokiN | lld:pubmed |
| pubmed-article:17895593 | pubmed:author | pubmed-author:HaraguchiMits... | lld:pubmed |
| pubmed-article:17895593 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17895593 | pubmed:volume | 105 | lld:pubmed |
| pubmed-article:17895593 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17895593 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17895593 | pubmed:pagination | 122-6 | lld:pubmed |
| pubmed-article:17895593 | pubmed:meshHeading | pubmed-meshheading:17895593... | lld:pubmed |
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| pubmed-article:17895593 | pubmed:meshHeading | pubmed-meshheading:17895593... | lld:pubmed |
| pubmed-article:17895593 | pubmed:meshHeading | pubmed-meshheading:17895593... | lld:pubmed |
| pubmed-article:17895593 | pubmed:meshHeading | pubmed-meshheading:17895593... | lld:pubmed |
| pubmed-article:17895593 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17895593 | pubmed:articleTitle | Nobiletin, a citrus flavonoid that improves memory impairment, rescues bulbectomy-induced cholinergic neurodegeneration in mice. | lld:pubmed |
| pubmed-article:17895593 | pubmed:affiliation | Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan. | lld:pubmed |
| pubmed-article:17895593 | pubmed:publicationType | Journal Article | lld:pubmed |
