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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-9-26
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pubmed:abstractText |
We have recently reported that nobiletin, a citrus flavonoid, improves impaired memory in olfactory-bulbectomized (OBX) mice, which have been widely utilized as a useful paradigm that shares some major clinical features of Alzheimer's disease. Here, we examined the effects of nobiletin on OBX-induced cholinergic neurodegeneration in mice. OBX mice showed reduced acetylcholinesterase (AChE) staining and choline acetyltransferase (ChAT) expression in the hippocampus. An 11-day administration of nobiletin rescued OBX-induced decrease in the density of AChE-staining and ChAT expression in the hippocampus. These results suggest that nobiletin rescues OBX-induced cholinergic neurodegeneration, accompanied by improvement of impaired memory in OBX mice.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1347-8613
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pubmed:author |
pubmed-author:HaraguchiMitsuyaM,
pubmed-author:KatoChiekoC,
pubmed-author:MimakiYoshihiroY,
pubmed-author:NakagawasaiOsamuO,
pubmed-author:NakajimaAkiraA,
pubmed-author:OhizumiYasushiY,
pubmed-author:OmaeNaokiN,
pubmed-author:SashidaYutakaY,
pubmed-author:SongSi-YoungSY,
pubmed-author:TadanoTakeshiT,
pubmed-author:YamakuniTohruT,
pubmed-author:YokosukaAkihitoA
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pubmed:issnType |
Print
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pubmed:volume |
105
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
122-6
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pubmed:meshHeading |
pubmed-meshheading:17895593-Acetylcholinesterase,
pubmed-meshheading:17895593-Animals,
pubmed-meshheading:17895593-Antioxidants,
pubmed-meshheading:17895593-Choline O-Acetyltransferase,
pubmed-meshheading:17895593-Cholinergic Fibers,
pubmed-meshheading:17895593-Citrus,
pubmed-meshheading:17895593-Flavones,
pubmed-meshheading:17895593-Flavonoids,
pubmed-meshheading:17895593-Male,
pubmed-meshheading:17895593-Memory Disorders,
pubmed-meshheading:17895593-Mice,
pubmed-meshheading:17895593-Models, Anatomic,
pubmed-meshheading:17895593-Molecular Structure,
pubmed-meshheading:17895593-Nerve Degeneration,
pubmed-meshheading:17895593-Olfactory Bulb
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pubmed:year |
2007
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pubmed:articleTitle |
Nobiletin, a citrus flavonoid that improves memory impairment, rescues bulbectomy-induced cholinergic neurodegeneration in mice.
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pubmed:affiliation |
Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
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pubmed:publicationType |
Journal Article
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