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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2007-9-25
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pubmed:abstractText |
Congenital hyperinsulinism (CH) is treated surgically in many centers (near-total and partial pancreatectomy for diffuse and focal disease respectively). Most patients treated with near-total pancreatectomy developed diabetes during childhood/puberty. CH patients are at increased risk of neurodevelopmental disorders, some being severe, which are reported to occur in 14-44% of patients from highly heterogenous cohorts. Over the last few decades, we have treated children with CH conservatively without surgery. The aim of this study was to assess the neurodevelopmental outcome of these patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1479-683X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
157
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
491-7
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pubmed:meshHeading |
pubmed-meshheading:17893264-ATP-Binding Cassette Transporters,
pubmed-meshheading:17893264-Adolescent,
pubmed-meshheading:17893264-Adult,
pubmed-meshheading:17893264-Brain,
pubmed-meshheading:17893264-Child,
pubmed-meshheading:17893264-Child Development,
pubmed-meshheading:17893264-Developmental Disabilities,
pubmed-meshheading:17893264-Diabetes Mellitus,
pubmed-meshheading:17893264-Follow-Up Studies,
pubmed-meshheading:17893264-Humans,
pubmed-meshheading:17893264-Mutation,
pubmed-meshheading:17893264-Nervous System,
pubmed-meshheading:17893264-Pancreatectomy,
pubmed-meshheading:17893264-Persistent Hyperinsulinemia Hypoglycemia of Infancy,
pubmed-meshheading:17893264-Potassium Channels,
pubmed-meshheading:17893264-Potassium Channels, Inwardly Rectifying,
pubmed-meshheading:17893264-Receptors, Drug,
pubmed-meshheading:17893264-Time Factors,
pubmed-meshheading:17893264-Treatment Outcome
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pubmed:year |
2007
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pubmed:articleTitle |
Long-term neurodevelopmental outcome in conservatively treated congenital hyperinsulinism.
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pubmed:affiliation |
Pediatric Endocrine Unit, Chaim Sheba Medical Center, Safra Children's Hospital, Tel Hashomer 52621, Israel. kineret@gmail.com
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pubmed:publicationType |
Journal Article,
Evaluation Studies
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