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rdf:type |
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lifeskim:mentions |
umls-concept:C0004099,
umls-concept:C0008059,
umls-concept:C0017337,
umls-concept:C0020846,
umls-concept:C0085129,
umls-concept:C0298130,
umls-concept:C0332281,
umls-concept:C0428539,
umls-concept:C0443626,
umls-concept:C1416932,
umls-concept:C1424972,
umls-concept:C1556095,
umls-concept:C1882417
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pubmed:issue |
10
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pubmed:dateCreated |
2007-9-21
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pubmed:abstractText |
As previous studies have shown that cysteinyl leukotrienes are important mediators in exercise-induced bronchoconstriction (EIB), and leukotriene receptor antagonists (LTRAs) such as montelukast have been shown to improve post-exercise bronchoconstrictor responses, we herein investigated whether clinical responsiveness to montelukast was associated with polymorphisms in the genes encoding leukotriene C4 synthase (LTC4S) and cysteinyl leukotriene receptor 1 (CysLTR1) and/or clinical parameters in Korean asthmatic children with EIB.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetates,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione Transferase,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin E,
http://linkedlifedata.com/resource/pubmed/chemical/Leukotriene Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Quinolines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Leukotriene,
http://linkedlifedata.com/resource/pubmed/chemical/leukotriene D4 receptor,
http://linkedlifedata.com/resource/pubmed/chemical/leukotriene-C4 synthase,
http://linkedlifedata.com/resource/pubmed/chemical/montelukast
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0954-7894
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1487-93
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pubmed:meshHeading |
pubmed-meshheading:17883728-Acetates,
pubmed-meshheading:17883728-Asthma, Exercise-Induced,
pubmed-meshheading:17883728-Bronchial Hyperreactivity,
pubmed-meshheading:17883728-Child,
pubmed-meshheading:17883728-Drug Resistance,
pubmed-meshheading:17883728-Female,
pubmed-meshheading:17883728-Glutathione Transferase,
pubmed-meshheading:17883728-Humans,
pubmed-meshheading:17883728-Immunoglobulin E,
pubmed-meshheading:17883728-Korea,
pubmed-meshheading:17883728-Leukotriene Antagonists,
pubmed-meshheading:17883728-Male,
pubmed-meshheading:17883728-Membrane Proteins,
pubmed-meshheading:17883728-Polymorphism, Genetic,
pubmed-meshheading:17883728-Prognosis,
pubmed-meshheading:17883728-Quinolines,
pubmed-meshheading:17883728-Receptors, Leukotriene,
pubmed-meshheading:17883728-Treatment Outcome
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pubmed:year |
2007
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pubmed:articleTitle |
Responsiveness to montelukast is associated with bronchial hyperresponsiveness and total immunoglobulin E but not polymorphisms in the leukotriene C4 synthase and cysteinyl leukotriene receptor 1 genes in Korean children with exercise-induced asthma (EIA).
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pubmed:affiliation |
Department of Pediatrics, Hangang Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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