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rdf:type |
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lifeskim:mentions |
umls-concept:C0007600,
umls-concept:C0033572,
umls-concept:C0162638,
umls-concept:C0332281,
umls-concept:C1171362,
umls-concept:C1326205,
umls-concept:C1335191,
umls-concept:C1518174,
umls-concept:C1660749,
umls-concept:C1709385,
umls-concept:C2931822
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pubmed:issue |
2
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pubmed:dateCreated |
2007-10-15
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pubmed:abstractText |
Prostate apoptosis response-4 (Par-4) is a proapoptotic gene that selectively induces cell death in most cancer cells. In addition to the increased percentage of apoptotic cells, caspase-3 activity, and poly (ADP-ribose) polymerase (PARP) cleavage, we demonstrate that elevated expression of Par-4 and nuclear entry resulted in apoptosis of nasopharyngeal carcinoma (NPC) cell lines either in serum deprivation or by ectopic overexpression of Par-4. Moreover, disassociation from the Par-4/Akt complex was correlated with the induced proapoptotic ability of Par-4. Therefore, our data suggest that the cytoplasmic localization and expression level of endogenous Par-4 in NPC cells are not sufficient to augment apoptosis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0304-3835
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
257
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
252-62
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17881119-Apoptosis,
pubmed-meshheading:17881119-Apoptosis Regulatory Proteins,
pubmed-meshheading:17881119-Blotting, Western,
pubmed-meshheading:17881119-Caspase 3,
pubmed-meshheading:17881119-Cell Line, Tumor,
pubmed-meshheading:17881119-Cell Nucleus,
pubmed-meshheading:17881119-Cell Survival,
pubmed-meshheading:17881119-Culture Media, Serum-Free,
pubmed-meshheading:17881119-Fluorescent Antibody Technique,
pubmed-meshheading:17881119-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:17881119-Humans,
pubmed-meshheading:17881119-Intracellular Fluid,
pubmed-meshheading:17881119-Nasopharyngeal Neoplasms,
pubmed-meshheading:17881119-Poly(ADP-ribose) Polymerases,
pubmed-meshheading:17881119-Protein Binding,
pubmed-meshheading:17881119-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:17881119-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:17881119-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17881119-Time Factors,
pubmed-meshheading:17881119-Transfection
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pubmed:year |
2007
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pubmed:articleTitle |
Protein expression and intracellular localization of prostate apoptosis response-4 (Par-4) are associated with apoptosis induction in nasopharyngeal carcinoma cell lines.
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pubmed:affiliation |
Department and Institute of Life Science, College of Life Science, Tzu-Chi University, 701, Sec. 3, Chung-Yang Road, Hualien 97071, Taiwan. jwlee@mail.tcu.edu.tw
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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