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rdf:type |
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lifeskim:mentions |
umls-concept:C0008652,
umls-concept:C0020456,
umls-concept:C0031678,
umls-concept:C0037083,
umls-concept:C0162638,
umls-concept:C0168424,
umls-concept:C0205263,
umls-concept:C0694888,
umls-concept:C0969698,
umls-concept:C1334043,
umls-concept:C1444748,
umls-concept:C1553877,
umls-concept:C1608885,
umls-concept:C1710082,
umls-concept:C1880274
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pubmed:issue |
14
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pubmed:dateCreated |
2007-10-2
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pubmed:abstractText |
Oxidative stress plays a causal role in vascular injury in diabetes mellitus, but the mechanisms and targets remain poorly understood.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Hypoglycemic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/PTEN Phosphohydrolase,
http://linkedlifedata.com/resource/pubmed/chemical/PTEN protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Peroxynitrous Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/Pten protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Reactive Nitrogen Species,
http://linkedlifedata.com/resource/pubmed/chemical/STK11 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Serine,
http://linkedlifedata.com/resource/pubmed/chemical/Threonine
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
2
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pubmed:volume |
116
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1585-95
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:17875968-Animals,
pubmed-meshheading:17875968-Apoptosis,
pubmed-meshheading:17875968-Cells, Cultured,
pubmed-meshheading:17875968-Diabetes Mellitus, Experimental,
pubmed-meshheading:17875968-Endothelium, Vascular,
pubmed-meshheading:17875968-Humans,
pubmed-meshheading:17875968-Hyperglycemia,
pubmed-meshheading:17875968-Hypoglycemic Agents,
pubmed-meshheading:17875968-Insulin,
pubmed-meshheading:17875968-Male,
pubmed-meshheading:17875968-Mice,
pubmed-meshheading:17875968-PTEN Phosphohydrolase,
pubmed-meshheading:17875968-Peroxynitrous Acid,
pubmed-meshheading:17875968-Phosphorylation,
pubmed-meshheading:17875968-Protein-Serine-Threonine Kinases,
pubmed-meshheading:17875968-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:17875968-Reactive Nitrogen Species,
pubmed-meshheading:17875968-Serine,
pubmed-meshheading:17875968-Signal Transduction,
pubmed-meshheading:17875968-Threonine,
pubmed-meshheading:17875968-Umbilical Veins,
pubmed-meshheading:17875968-Up-Regulation
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pubmed:year |
2007
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pubmed:articleTitle |
Reactive nitrogen species induced by hyperglycemia suppresses Akt signaling and triggers apoptosis by upregulating phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10) in an LKB1-dependent manner.
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pubmed:affiliation |
Section of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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