Source:http://linkedlifedata.com/resource/pubmed/id/17867599
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2007-9-17
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| pubmed:abstractText |
Suppressors of cytokine signaling (SOCS) negatively regulate Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling involved in proliferation, survival, and apoptosis. We previously showed a loss of SOCS-1 function due to deleterious mutations in a major subset of mediastinal B-cell lymphoma (MBL). In MBL cell lines this leads to retarded JAK2 degradation and sustained phospho-STAT5 action results in enhanced DNA binding of phospho-STAT5.
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| pubmed:language |
ger
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0070-4113
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
90
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
210-5
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| pubmed:meshHeading |
pubmed-meshheading:17867599-Cell Nucleus,
pubmed-meshheading:17867599-Humans,
pubmed-meshheading:17867599-Lymphoma, B-Cell,
pubmed-meshheading:17867599-Lymphoma, Non-Hodgkin,
pubmed-meshheading:17867599-Mutation,
pubmed-meshheading:17867599-Phosphorylation,
pubmed-meshheading:17867599-Reed-Sternberg Cells,
pubmed-meshheading:17867599-STAT5 Transcription Factor,
pubmed-meshheading:17867599-Suppressor of Cytokine Signaling Proteins
|
| pubmed:year |
2006
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| pubmed:articleTitle |
[Mutations of the tumor suppressor gene SOCS-1 in classical Hodgkin lymphoma are frequent and associated with nuclear phospho-STAT5 accumulation].
|
| pubmed:affiliation |
Abteilung Pathologie, Universität Ulm.
|
| pubmed:publicationType |
Journal Article,
English Abstract
|