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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2007-9-17
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pubmed:abstractText |
Gangliosides, i. e. sialic acid containing glycosphingolipids, constitute a major component of neuronal cells and are thought to be essential for brain function. UDP-glucose: ceramide glucosyl-transferase (Ugcg) catalyzes the initial step of glycosphingolipid (GSL) biosynthesis. A total deletion of the Ugcg-gene in mice led to embryonic lethality. In order to gain insight into the role of gangliosides in brain development and function, a cell specific disruption of Ugcg was performed.
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pubmed:language |
ger
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0070-4113
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
90
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
193-202
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pubmed:meshHeading |
pubmed-meshheading:17867597-Animals,
pubmed-meshheading:17867597-Axons,
pubmed-meshheading:17867597-Brain,
pubmed-meshheading:17867597-Cerebellum,
pubmed-meshheading:17867597-Female,
pubmed-meshheading:17867597-Gene Deletion,
pubmed-meshheading:17867597-Glucosyltransferases,
pubmed-meshheading:17867597-Glycosphingolipids,
pubmed-meshheading:17867597-Mice,
pubmed-meshheading:17867597-Mice, Knockout,
pubmed-meshheading:17867597-Neural Tube Defects,
pubmed-meshheading:17867597-Neurons,
pubmed-meshheading:17867597-Peripheral Nervous System,
pubmed-meshheading:17867597-Pregnancy,
pubmed-meshheading:17867597-Purkinje Cells
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pubmed:year |
2006
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pubmed:articleTitle |
[Cell-specific deletion of glucosylceramide synthase in brain leads to severe neural defects after birth].
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pubmed:affiliation |
Zelluläre und Molekulare Pathologie, Deutsches Krebsforschungszentrum, Heidelberg.
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pubmed:publicationType |
Journal Article,
English Abstract
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