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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2008-1-14
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pubmed:abstractText |
Motivational effects of self-administered ethanol have rarely been studied in preweanling rats due primarily to the lack of age-appropriate operant tasks. The present experiments assessed the hedonic effects of intraoral ethanol in infant rats self-administered by activating a touch sensor. On postnatal day (PD) 13 pups were pre-exposed to the drug's pharmacological and/or sensory effects. Operant sessions were conducted during PDs 14-16 (Experiments 1 and 2). Paired animals were placed in chambers equipped with a touch-sensitive disk and received an intraoral infusion of ethanol (3 or 5% v/v, 5 microl) after each sensor contact. Yoked controls were equated for number and distribution of ethanol infusions but had no control over the contingency between operant behavior and intraoral infusion. In Experiment 2, training trials were preceded by a non-reinforced phase. Paired pups performed fewer operant responses than controls and decreased their operant responses across sessions. These results suggest that intraoral self-administered ethanol has an aversive hedonic value in two-week old rats. Operant behavior seems to have been associated with aversive orosensory effects derived from intraoral ethanol infusion.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17854847-10027504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17854847-11199282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17854847-11770062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17854847-12045472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17854847-12785286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17854847-15252290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17854847-15976517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17854847-16396743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17854847-16499482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17854847-16713505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17854847-16930208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17854847-16930213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17854847-16953003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17854847-17010438,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17854847-17386073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17854847-2078162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17854847-2721821,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17854847-3067600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17854847-3067601,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17854847-3137617,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17854847-3530023,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17854847-3828062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17854847-3952173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17854847-7708363,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17854847-7857239,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17854847-8397876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17854847-8442898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17854847-8446672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17854847-8833099,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17854847-9194933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17854847-9718105
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0031-9384
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
28
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pubmed:volume |
93
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
118-29
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pubmed:dateRevised |
2011-2-8
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pubmed:meshHeading |
pubmed-meshheading:17854847-Administration, Oral,
pubmed-meshheading:17854847-Age Factors,
pubmed-meshheading:17854847-Analysis of Variance,
pubmed-meshheading:17854847-Animals,
pubmed-meshheading:17854847-Association Learning,
pubmed-meshheading:17854847-Avoidance Learning,
pubmed-meshheading:17854847-Central Nervous System Depressants,
pubmed-meshheading:17854847-Conditioning, Operant,
pubmed-meshheading:17854847-Ethanol,
pubmed-meshheading:17854847-Exploratory Behavior,
pubmed-meshheading:17854847-Matched-Pair Analysis,
pubmed-meshheading:17854847-Models, Animal,
pubmed-meshheading:17854847-Motivation,
pubmed-meshheading:17854847-Rats,
pubmed-meshheading:17854847-Rats, Sprague-Dawley,
pubmed-meshheading:17854847-Reinforcement (Psychology),
pubmed-meshheading:17854847-Self Administration
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pubmed:year |
2008
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pubmed:articleTitle |
Motivational effects of intraorally-infused ethanol in rat pups in an operant self-administration task.
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pubmed:affiliation |
Center for Developmental Psychobiology, Binghamton University, Binghamton, NY 13902-6000, USA. pautassi@binghamton.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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