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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2008-1-15
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pubmed:abstractText |
Chromatin remodeling through histone acetylation is a key control mechanism in gene transcription. We have shown previously that fluid resuscitation in rodents is coupled with highly structured post-translational modifications of cardiac histones. The current experiment was performed to validate this concept in a clinically relevant large animal model of hemorrhage and resuscitation, and to correlate the changes in histone acetylation with altered expression of immediate-early response genes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0300-9572
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pubmed:author |
pubmed-author:AhujaNareshN,
pubmed-author:AlamHasan BHB,
pubmed-author:AyusteEduardo CEC,
pubmed-author:ChenHuazhenH,
pubmed-author:KoustovaElenaE,
pubmed-author:LiYongqingY,
pubmed-author:LiuBaolingB,
pubmed-author:SailhamerElizabeth AEA,
pubmed-author:ShultsChristianC,
pubmed-author:VelmahosGeorge CGC,
pubmed-author:de MoyaMarcM
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pubmed:issnType |
Print
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pubmed:volume |
76
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
299-310
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:17822827-Acetylation,
pubmed-meshheading:17822827-Animals,
pubmed-meshheading:17822827-Blotting, Western,
pubmed-meshheading:17822827-Cell Adhesion Molecules, Neuronal,
pubmed-meshheading:17822827-Chromatin Immunoprecipitation,
pubmed-meshheading:17822827-Contactins,
pubmed-meshheading:17822827-Disease Models, Animal,
pubmed-meshheading:17822827-Histones,
pubmed-meshheading:17822827-Resuscitation,
pubmed-meshheading:17822827-Shock, Hemorrhagic,
pubmed-meshheading:17822827-Swine,
pubmed-meshheading:17822827-Transcription, Genetic,
pubmed-meshheading:17822827-Zebrafish Proteins
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pubmed:year |
2008
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pubmed:articleTitle |
Impact of resuscitation strategies on the acetylation status of cardiac histones in a swine model of hemorrhage.
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pubmed:affiliation |
Trauma Research and Readiness Institute for Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, United States. hbalam@partners.org
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, Non-P.H.S.
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