Source:http://linkedlifedata.com/resource/pubmed/id/17822725
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2008-2-19
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| pubmed:abstractText |
Human lymphatic vessels express several leukocyte adhesion molecules. The study here investigated the expression of three junctional adhesion molecules (JAM) which are a newly reported glycoprotein family of adhesion molecules on human lymphatic endothelium. In this study, JAM-1 and JAM-3 but not JAM-2 were detected in cultured human neonatal dermal lymphatic endothelial cells (LEC) at the gene and protein levels by microarray, RT-PCR, real-time PCR, and immunohistochemical analysis. The JAM-1 and JAM-3 expression was not altered in the TNF-alpha-treated LEC or in the untreated cells. In human tissue, the expression of JAM-1, and the expression of JAM-1, JAM-2, and JAM-3 were observed in collecting lymphatic vessels of uninflamed small intestine, and in initial lymphatics of inflamed tongue and uninflamed gingival tissue. It is thought that JAM-2 mRNA could be produced in mature vascular endothelium but not in cultured cells, and that human intestinal and oral lymphatic vessels usually express JAM-1, JAM-2, and JAM-3. There were initial lymphatics simultaneously expressing JAM-1, JAM-2, and JAM-3 in the mucosal connective tissue papillae of gingival tissue. The three JAM expressions on the lymphatic endothelium may contribute to both seal the cell-cell contact at interendothelial junctions and also allow lymphocytes to transmigrate into lymphatic vessels from tissue, independent of inflammatory cytokines.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/F11R protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/JAM2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/JAM3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/junctional adhesion molecule
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| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
0026-2862
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
75
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
269-78
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| pubmed:meshHeading |
pubmed-meshheading:17822725-Adolescent,
pubmed-meshheading:17822725-Adult,
pubmed-meshheading:17822725-Aged,
pubmed-meshheading:17822725-Cell Adhesion Molecules,
pubmed-meshheading:17822725-Cells, Cultured,
pubmed-meshheading:17822725-Endothelial Cells,
pubmed-meshheading:17822725-Endothelium, Lymphatic,
pubmed-meshheading:17822725-Enteritis,
pubmed-meshheading:17822725-Gingiva,
pubmed-meshheading:17822725-Humans,
pubmed-meshheading:17822725-Inflammation,
pubmed-meshheading:17822725-Intestine, Small,
pubmed-meshheading:17822725-Middle Aged,
pubmed-meshheading:17822725-Periodontitis,
pubmed-meshheading:17822725-RNA, Messenger,
pubmed-meshheading:17822725-Receptors, Cell Surface,
pubmed-meshheading:17822725-Tight Junctions,
pubmed-meshheading:17822725-Tongue,
pubmed-meshheading:17822725-Tumor Necrosis Factor-alpha
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| pubmed:year |
2008
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| pubmed:articleTitle |
Expression of junctional adhesion molecules on the human lymphatic endothelium.
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| pubmed:affiliation |
Department of Oral Growth and Development, Fukuoka Dental College, 2-15-1 Tamura, Sawara-Ku, Fukuoka, 814-0193, Japan.
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| pubmed:publicationType |
Journal Article
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