rdf:type |
|
lifeskim:mentions |
umls-concept:C0019704,
umls-concept:C0034790,
umls-concept:C0039194,
umls-concept:C0041432,
umls-concept:C0080194,
umls-concept:C0085358,
umls-concept:C0205369,
umls-concept:C0271510,
umls-concept:C0439605,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1706438,
umls-concept:C2698600
|
pubmed:issue |
22
|
pubmed:dateCreated |
2007-10-29
|
pubmed:abstractText |
Human immunodeficiency virus type 1 (HIV-1) cytotoxic T-lymphocyte escape mutations represent both a major reason for loss of HIV immune control and a considerable challenge for HIV-1 vaccine design. Previous data suggest that initial HIV-1-specific CD8(+) T-cell responses are determined largely by viral and host genetics, but the mechanisms influencing the subsequent viral evolution are unclear. Here, we show a random recruitment of T-cell receptor (TCR) alpha and beta clonotypes of the initial HIV-1-specific CD8(+) T cells during primary infection in two genetically identical twins infected simultaneously with the same virus, suggesting that stochastic TCR recruitment of HIV-1-specific CD8(+) T cells contributes to the diverse and unpredictable HIV-1 sequence evolution.
|
pubmed:commentsCorrections |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Nov
|
pubmed:issn |
0022-538X
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
81
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
12666-9
|
pubmed:dateRevised |
2009-11-18
|
pubmed:meshHeading |
pubmed-meshheading:17804503-Amino Acid Sequence,
pubmed-meshheading:17804503-CD8-Positive T-Lymphocytes,
pubmed-meshheading:17804503-Diseases in Twins,
pubmed-meshheading:17804503-Epitopes, T-Lymphocyte,
pubmed-meshheading:17804503-Evolution, Molecular,
pubmed-meshheading:17804503-HIV Infections,
pubmed-meshheading:17804503-HIV-1,
pubmed-meshheading:17804503-Humans,
pubmed-meshheading:17804503-Molecular Sequence Data,
pubmed-meshheading:17804503-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:17804503-Twins, Monozygotic
|
pubmed:year |
2007
|
pubmed:articleTitle |
Random T-cell receptor recruitment in human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cells from genetically identical twins infected with the same HIV-1 strain.
|
pubmed:affiliation |
Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA.
|
pubmed:publicationType |
Journal Article,
Twin Study
|