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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
28
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pubmed:dateCreated |
2007-10-1
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pubmed:abstractText |
Denosumab, a fully human monoclonal antibody to receptor activator of nuclear factor-kappaB ligand, suppresses bone resorption. In this study, we evaluated the efficacy and safety of five dosing regimens of denosumab in patients with breast cancer-related bone metastases not previously treated with intravenous bisphosphonates (IV BPs).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1527-7755
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pubmed:author |
pubmed-author:AlvaradoCristinaC,
pubmed-author:BerardiRossanaR,
pubmed-author:BodyJean-JacquesJJ,
pubmed-author:ColemanRobertR,
pubmed-author:FanMichelleM,
pubmed-author:FigueroaJazminJ,
pubmed-author:GasconPereP,
pubmed-author:JunSusieS,
pubmed-author:KinseyAmyA,
pubmed-author:LiptonAllanA,
pubmed-author:PatersonAlexander H GAH,
pubmed-author:PetersonMark CMC,
pubmed-author:Solal-CelignyPhilippeP,
pubmed-author:StegerGuenther GGG,
pubmed-author:TonkinKatia SKS,
pubmed-author:de BoerRichardR
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4431-7
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:17785705-Adult,
pubmed-meshheading:17785705-Aged,
pubmed-meshheading:17785705-Aged, 80 and over,
pubmed-meshheading:17785705-Antibodies, Monoclonal,
pubmed-meshheading:17785705-Biological Markers,
pubmed-meshheading:17785705-Bone Density Conservation Agents,
pubmed-meshheading:17785705-Bone Neoplasms,
pubmed-meshheading:17785705-Bone Resorption,
pubmed-meshheading:17785705-Breast Neoplasms,
pubmed-meshheading:17785705-Collagen Type I,
pubmed-meshheading:17785705-Computer Simulation,
pubmed-meshheading:17785705-Double-Blind Method,
pubmed-meshheading:17785705-Drug Administration Schedule,
pubmed-meshheading:17785705-Drug Toxicity,
pubmed-meshheading:17785705-Female,
pubmed-meshheading:17785705-Humans,
pubmed-meshheading:17785705-Infusions, Intravenous,
pubmed-meshheading:17785705-Injections, Subcutaneous,
pubmed-meshheading:17785705-Kaplan-Meier Estimate,
pubmed-meshheading:17785705-Middle Aged,
pubmed-meshheading:17785705-Peptides,
pubmed-meshheading:17785705-RANK Ligand
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pubmed:year |
2007
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pubmed:articleTitle |
Randomized active-controlled phase II study of denosumab efficacy and safety in patients with breast cancer-related bone metastases.
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pubmed:affiliation |
Penn State Milton S. Hershey Medical Center, Hershey, PA 17033-0850, USA. alipton@psu.edu
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study,
Clinical Trial, Phase II
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