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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
Pt 12
pubmed:dateCreated
2007-12-6
pubmed:abstractText
We investigated the pathogenic mechanisms of hippocampal structural changes and neuronal activation in a kainic acid (KA)-treated rat model using non-invasive high-resolution diffusion-weighted imaging, T2-weighted imaging, and manganese-enhanced magnetic resonance imaging (MEMRI). We found that high-resolution MRI can reveal KA-induced subtle lesions in hippocampus. The signal changes were first observed in the CA3 area and then the CA1 area, and were revealed to be focal edema and neuronal death in histopathological studies. MR signal intensity was higher in CA1 area than in CA3 area at 168 h post KA treatment due to the increase of proliferating astrocytes as shown by histopathological studies. MEMRI studies revealed signal hyperintensity in the CA3 pyramidal cell layer after KA treatment, and the MEMRI signal can be attenuated by diltiazem, an L-type calcium channel blocker. Histopathological study revealed attenuation of focal edema and neuronal swelling following diltiazem treatment. It indicated that KA-induced neuronal activation mainly developed in CA3, and calcium channels may play important roles in pathogenesis of KA-induced hippocampal lesions. We conclude that high-resolution MRI is able to identify KA-induced hippocampal damage, and that MEMRI can be used to investigate the role of calcium channels in the pathogenic mechanisms of neurological conditions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1460-2156
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
130
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3124-34
pubmed:meshHeading
pubmed-meshheading:17785345-Animals, pubmed-meshheading:17785345-Behavior, Animal, pubmed-meshheading:17785345-Brain Edema, pubmed-meshheading:17785345-Brain Mapping, pubmed-meshheading:17785345-Calcium Channel Blockers, pubmed-meshheading:17785345-Diltiazem, pubmed-meshheading:17785345-Disease Models, Animal, pubmed-meshheading:17785345-Epilepsy, Temporal Lobe, pubmed-meshheading:17785345-Excitatory Amino Acid Agonists, pubmed-meshheading:17785345-Gadolinium DTPA, pubmed-meshheading:17785345-Hippocampus, pubmed-meshheading:17785345-Kainic Acid, pubmed-meshheading:17785345-Magnesium, pubmed-meshheading:17785345-Magnetic Resonance Imaging, pubmed-meshheading:17785345-Male, pubmed-meshheading:17785345-Neurons, pubmed-meshheading:17785345-Proto-Oncogene Proteins c-fos, pubmed-meshheading:17785345-Rats, pubmed-meshheading:17785345-Rats, Sprague-Dawley
pubmed:year
2007
pubmed:articleTitle
Multiparametric MRI evaluation of kainic acid-induced neuronal activation in rat hippocampus.
pubmed:affiliation
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, ROC.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't