rdf:type |
|
lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0008497,
umls-concept:C0017262,
umls-concept:C0018062,
umls-concept:C0021966,
umls-concept:C0086418,
umls-concept:C0142963,
umls-concept:C0185117,
umls-concept:C0243144,
umls-concept:C1280500,
umls-concept:C2911684
|
pubmed:issue |
10
|
pubmed:dateCreated |
2007-10-15
|
pubmed:abstractText |
Active placental transport of maternal iodide by the thyroidal sodium iodide symporter (NIS) provides an essential substrate for fetal thyroid hormone synthesis. NIS is expressed in trophoblast and is regulated by human choriogonadotropin (hCG). In thyroid, iodide down-regulates expression of several genes including NIS. Placentas of iodine-deficient rats demonstrate up-regulation of NIS mRNA, suggesting a role for iodide in regulating placental NIS.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antithyroid Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Chorionic Gonadotropin,
http://linkedlifedata.com/resource/pubmed/chemical/Dithiothreitol,
http://linkedlifedata.com/resource/pubmed/chemical/Iodine,
http://linkedlifedata.com/resource/pubmed/chemical/Iodine Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Propylthiouracil,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Symporters,
http://linkedlifedata.com/resource/pubmed/chemical/Trace Elements,
http://linkedlifedata.com/resource/pubmed/chemical/sodium-iodide symporter
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
|
pubmed:issn |
0021-972X
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pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
92
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
4046-51
|
pubmed:meshHeading |
pubmed-meshheading:17726079-Antithyroid Agents,
pubmed-meshheading:17726079-Cell Line, Tumor,
pubmed-meshheading:17726079-Choriocarcinoma,
pubmed-meshheading:17726079-Chorionic Gonadotropin,
pubmed-meshheading:17726079-Dithiothreitol,
pubmed-meshheading:17726079-Female,
pubmed-meshheading:17726079-Gene Expression,
pubmed-meshheading:17726079-Humans,
pubmed-meshheading:17726079-Iodine,
pubmed-meshheading:17726079-Iodine Radioisotopes,
pubmed-meshheading:17726079-Propylthiouracil,
pubmed-meshheading:17726079-RNA, Messenger,
pubmed-meshheading:17726079-Symporters,
pubmed-meshheading:17726079-Thyroid Gland,
pubmed-meshheading:17726079-Trace Elements,
pubmed-meshheading:17726079-Trophoblasts,
pubmed-meshheading:17726079-Uterine Neoplasms
|
pubmed:year |
2007
|
pubmed:articleTitle |
Effect of Iodide on Human Choriogonadotropin, Sodium-Iodide Symporter Expression, and Iodide Uptake in BeWo Choriocarcinoma Cells.
|
pubmed:affiliation |
Department of Endocrinology, Conjoint Endocrine Laboratory, Royal Brisbane and Women's Hospital and Queensland Health Pathology Services, Brisbane, Queensland 4029, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|