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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1992-2-24
|
| pubmed:abstractText |
The effects of Zn2+ combined with either chlorhexidine or cetylpyridinium chloride (CPC) on caries incidence in partially desalivated rats were investigated. Seven groups of 12 animals each received topical applications for 20 s with a saturated swab (0.2 ml) of the following aqueous solutions twice daily on weekdays (10 a.m. and 3 p.m.) and once daily during weekends (12 a.m.) for 5 wk: deionized water (placebo); 40 mM zinc acetate; 2.2 mM chlorhexidine diacetate; 4.4 mM CPC; 40 mM zinc acetate and 2.2 mM chlorhexidine diacetate; 40 mM zinc acetate and 4.4 mM CPC; and 20 mM NaF (positive control). Coronal caries was scored by the method of Keyes. All treatments except CPC alone resulted in significantly (P less than 0.05, ANOVA) less smooth-surface caries than did the placebo. NaF treatment resulted in significantly less smooth-surface caries than did Zn2+, chlorhexidine, CPC, and Zn(2+)-CPC. The inclusion of zinc ions did not significantly increase the caries-inhibitory efficacy of chlorhexidine (CH). The combination of Zn(2+)-CPC decreased smooth-surface scores significantly more than did CPC alone. Significant differences in sulcal-surface caries were not observed among the groups. Zn(2+)-CPC suppressed the Streptococcus sobrinus counts significantly more than did the separate agents. Animals treated with Zn(2+)-CH harbored the lowest populations of S. sobrinus.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
D
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Cetylpyridinium,
http://linkedlifedata.com/resource/pubmed/chemical/Chlorhexidine,
http://linkedlifedata.com/resource/pubmed/chemical/Drug Combinations,
http://linkedlifedata.com/resource/pubmed/chemical/Placebos,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium Fluoride,
http://linkedlifedata.com/resource/pubmed/chemical/Zinc,
http://linkedlifedata.com/resource/pubmed/chemical/Zinc Acetate
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0029-845X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
99
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
301-9
|
| pubmed:dateRevised |
2010-10-21
|
| pubmed:meshHeading |
pubmed-meshheading:1771376-Acetic Acids,
pubmed-meshheading:1771376-Administration, Topical,
pubmed-meshheading:1771376-Animals,
pubmed-meshheading:1771376-Cetylpyridinium,
pubmed-meshheading:1771376-Chlorhexidine,
pubmed-meshheading:1771376-Dental Caries,
pubmed-meshheading:1771376-Drug Combinations,
pubmed-meshheading:1771376-Female,
pubmed-meshheading:1771376-Incidence,
pubmed-meshheading:1771376-Male,
pubmed-meshheading:1771376-Placebos,
pubmed-meshheading:1771376-Rats,
pubmed-meshheading:1771376-Rats, Inbred Strains,
pubmed-meshheading:1771376-Saliva,
pubmed-meshheading:1771376-Sodium Fluoride,
pubmed-meshheading:1771376-Streptococcus mutans,
pubmed-meshheading:1771376-Xerostomia,
pubmed-meshheading:1771376-Zinc,
pubmed-meshheading:1771376-Zinc Acetate
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Combined effects of Zn(2+)-chlorhexidine and Zn(2+)-cetylpyridinium chloride on caries incidence in partially desalivated rats.
|
| pubmed:affiliation |
Department of Dental Research, University of Rochester, New York.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|