| pubmed-article:17713553 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17713553 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:17713553 | lifeskim:mentions | umls-concept:C0025166 | lld:lifeskim |
| pubmed-article:17713553 | lifeskim:mentions | umls-concept:C0032463 | lld:lifeskim |
| pubmed-article:17713553 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:17713553 | lifeskim:mentions | umls-concept:C0018284 | lld:lifeskim |
| pubmed-article:17713553 | lifeskim:mentions | umls-concept:C1947989 | lld:lifeskim |
| pubmed-article:17713553 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:17713553 | lifeskim:mentions | umls-concept:C1880177 | lld:lifeskim |
| pubmed-article:17713553 | lifeskim:mentions | umls-concept:C0205227 | lld:lifeskim |
| pubmed-article:17713553 | lifeskim:mentions | umls-concept:C1516960 | lld:lifeskim |
| pubmed-article:17713553 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:17713553 | pubmed:dateCreated | 2007-11-21 | lld:pubmed |
| pubmed-article:17713553 | pubmed:abstractText | In the present study, we report that media conditioned by polycythemia vera (PV) CD3+ cells promote BFU-E and CFU-Mk colony formation by both cord blood and PV peripheral blood CD34+ cells in the absence of exogenous cytokines and promoting megakaryocyte proplatelet formation. CD3+ cells constitutively produce elevated levels of IL-11, while stimulation with the addition of phytohemagglutinin (PHA) increased GM-CSF levels in most of the patients with PV. Anti-IL-11-neutralizing antibody partially inhibited the formation of BFU-E and CFU-Mk colonies promoted by PV CD3+ cell-conditioned media. Although IL-11 is not produced by normal T cells, real-time PCR and flow cytometric analysis showed that IL-11 was upregulated in the CD3+ cells of most PV patients as compared to normal CD3+ cells. In addition, a greater percentage of BFU-E colonies formed by PV CD34+ cells in the presence of PV CD3+ cell-conditioned media alone were JAK2V617F-positive as compared with that induced by EPO. We conclude that dysregulated production of soluble growth factor(s), including IL-11 and GM-CSF by PV T cells, contributes to the in vitro formation of erythroid colonies in the absence of exogenous cytokines by PV CD34+ cells and likely plays a role in sustaining hematopoiesis in PV. | lld:pubmed |
| pubmed-article:17713553 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17713553 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:17713553 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17713553 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17713553 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17713553 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17713553 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17713553 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17713553 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17713553 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17713553 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:17713553 | pubmed:issn | 1476-5551 | lld:pubmed |
| pubmed-article:17713553 | pubmed:author | pubmed-author:IshiiTT | lld:pubmed |
| pubmed-article:17713553 | pubmed:author | pubmed-author:HoffmanRR | lld:pubmed |
| pubmed-article:17713553 | pubmed:author | pubmed-author:ZhaiSS | lld:pubmed |
| pubmed-article:17713553 | pubmed:author | pubmed-author:GAUJ AJA | lld:pubmed |
| pubmed-article:17713553 | pubmed:author | pubmed-author:ShaRR | lld:pubmed |
| pubmed-article:17713553 | pubmed:author | pubmed-author:SozerSS | lld:pubmed |
| pubmed-article:17713553 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:17713553 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:17713553 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17713553 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17713553 | pubmed:pagination | 2433-41 | lld:pubmed |
| pubmed-article:17713553 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:17713553 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17713553 | pubmed:articleTitle | T cells from patients with polycythemia vera elaborate growth factors which contribute to endogenous erythroid and megakaryocyte colony formation. | lld:pubmed |
| pubmed-article:17713553 | pubmed:affiliation | Division of Hematology/Oncology, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029-6574, USA. | lld:pubmed |
| pubmed-article:17713553 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17713553 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:17713553 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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