Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2007-10-9
pubmed:abstractText
We have used time-lapse imaging to study cisplatin-induced hair cell death in lateral line neuromasts of zebrafish larvae in vivo. We found that cisplatin-induced hair cell death occurred much more slowly than had been shown to occur in aminoglycoside-induced hair cell death. By prelabeling hair cells with FM1-43FX, and assessing hair cell damage, it was established that cisplatin causes hair cell loss in the lateral line in a dose-dependent fashion. The kinetics of hair cell loss during exposure to different concentrations of cisplatin was also assessed and it was found that the onset of hair cell loss correlated with the accumulated dose of cisplatin. These data demonstrate the feasibility and repeatability of cisplatin damage protocols in the zebrafish lateral line and set the stage for future evaluations of modulation of cisplatin-induced hair cell death.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17709218-10575111, http://linkedlifedata.com/resource/pubmed/commentcorrection/17709218-10748326, http://linkedlifedata.com/resource/pubmed/commentcorrection/17709218-10771194, http://linkedlifedata.com/resource/pubmed/commentcorrection/17709218-10813781, http://linkedlifedata.com/resource/pubmed/commentcorrection/17709218-10831873, http://linkedlifedata.com/resource/pubmed/commentcorrection/17709218-10831874, http://linkedlifedata.com/resource/pubmed/commentcorrection/17709218-10842609, http://linkedlifedata.com/resource/pubmed/commentcorrection/17709218-12003999, http://linkedlifedata.com/resource/pubmed/commentcorrection/17709218-12073232, http://linkedlifedata.com/resource/pubmed/commentcorrection/17709218-12805553, http://linkedlifedata.com/resource/pubmed/commentcorrection/17709218-12943374, http://linkedlifedata.com/resource/pubmed/commentcorrection/17709218-14605921, http://linkedlifedata.com/resource/pubmed/commentcorrection/17709218-14644458, http://linkedlifedata.com/resource/pubmed/commentcorrection/17709218-15019990, http://linkedlifedata.com/resource/pubmed/commentcorrection/17709218-15091230, http://linkedlifedata.com/resource/pubmed/commentcorrection/17709218-15125271, http://linkedlifedata.com/resource/pubmed/commentcorrection/17709218-15567610, http://linkedlifedata.com/resource/pubmed/commentcorrection/17709218-15604295, http://linkedlifedata.com/resource/pubmed/commentcorrection/17709218-16014323, http://linkedlifedata.com/resource/pubmed/commentcorrection/17709218-16459035, http://linkedlifedata.com/resource/pubmed/commentcorrection/17709218-16519324, http://linkedlifedata.com/resource/pubmed/commentcorrection/17709218-16847145, http://linkedlifedata.com/resource/pubmed/commentcorrection/17709218-17113254, http://linkedlifedata.com/resource/pubmed/commentcorrection/17709218-17394157, http://linkedlifedata.com/resource/pubmed/commentcorrection/17709218-3129204, http://linkedlifedata.com/resource/pubmed/commentcorrection/17709218-6088023, http://linkedlifedata.com/resource/pubmed/commentcorrection/17709218-7198012, http://linkedlifedata.com/resource/pubmed/commentcorrection/17709218-747905, http://linkedlifedata.com/resource/pubmed/commentcorrection/17709218-7623136, http://linkedlifedata.com/resource/pubmed/commentcorrection/17709218-7838482, http://linkedlifedata.com/resource/pubmed/commentcorrection/17709218-7973504, http://linkedlifedata.com/resource/pubmed/commentcorrection/17709218-8951454, http://linkedlifedata.com/resource/pubmed/commentcorrection/17709218-8995510, http://linkedlifedata.com/resource/pubmed/commentcorrection/17709218-9119753, http://linkedlifedata.com/resource/pubmed/commentcorrection/17709218-9137523, http://linkedlifedata.com/resource/pubmed/commentcorrection/17709218-9248736, http://linkedlifedata.com/resource/pubmed/commentcorrection/17709218-9353848
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0378-5955
pubmed:author
pubmed:issnType
Print
pubmed:volume
233
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
46-53
pubmed:dateRevised
2011-5-10
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Cisplatin-induced hair cell loss in zebrafish (Danio rerio) lateral line.
pubmed:affiliation
Virginia Merrill Bloedel Hearing Research Center, University of Washington, Box 357923, Seattle, WA 98195, USA. henryou@u.washington.edu
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural