Linked Life Data

17707644

Source:http://linkedlifedata.com/resource/pubmed/id/17707644

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
21
pubmed:dateCreated
2007-9-17
pubmed:abstractText
A novel series of aminothiazonaphthalimides, A(1-2) and B(1-2), has been regioselectively synthesized. The linear compounds B(1-2) were evaluated to be far more active than their angular isomers A(1-2) in antitumor evaluation. The linear compounds C-F, derived from compound B(1), all showed highly efficient antitumor activities against A549 and P388 cell lines. Also, cytotoxicities of these four analogues against two tumor cells were highly dependent on the length of the side chains. The compound A(1) or B(1), with two methylene units in the side chain, was more cytotoxic than its corresponding homologue A(2) or B(2), with one more methylene unit.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0968-0896
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6846-51
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Highly efficient antitumor agents of heterocycles containing sulfur atom: linear and angular thiazonaphthalimides against human lung cancer cell in vitro.
pubmed:affiliation
State Key Laboratory of Bioreactor Engineering and Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, China. xhqian@ecust.edu.cn
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't