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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2007-9-10
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pubmed:abstractText |
Maytenus ilicifolia Mart. ex. Reissek (Celastraceae), a medicinal plant known in Brazil as "espinheira-santa" is commonly used to treat gastric disorders. The effect of the flavonoid-rich fraction separated from the leaves was evaluated for its gastroprotective properties and the mechanism(s) involved in this activity. Intraperitoneal administration of the flavonoid-rich fraction potently protected rats from experimentally induced chronic (ED(50)=79 mg/kg) and acute gastric lesions by ethanol (ED(50)=25mg/kg) and indomethacin (ED(50)=4 mg/kg) without altering the decreased amount of cytoprotective glutathione and mucus amount in the injured gastric mucosa. A potent reduction of gastric acid hypersecretion (ED(50)=7 mg/kg, i.p.) was accompanied by a reduction of nitric oxide release (ED(50)=1.6 mg/kg, i.p.) in the gastric secretion of 2h pylorus ligated rats which suggests an important role for nitric oxide-dependent mechanisms. Inhibition of gastric acid secretion in vivo was correlated with the in vitro inhibition of rabbit gastric H(+),K(+)-ATPase activity (IC(50)=41 microg/mL). Chemical investigation of the fraction showed galactitol (25%), epicatechin (3.1%) and catechin (2%) as the majoritary components. Collectively, the results show that the flavonoid-rich fraction of Maytenus ilicifolia potently protects animals from gastric lesions with high potency through inhibition of gastric acid secretion.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0378-8741
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
25
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pubmed:volume |
113
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
433-40
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pubmed:meshHeading |
pubmed-meshheading:17706386-Acetic Acid,
pubmed-meshheading:17706386-Animals,
pubmed-meshheading:17706386-Female,
pubmed-meshheading:17706386-Flavonoids,
pubmed-meshheading:17706386-Gastric Acid,
pubmed-meshheading:17706386-Gastric Juice,
pubmed-meshheading:17706386-Gastric Mucosa,
pubmed-meshheading:17706386-Glutathione,
pubmed-meshheading:17706386-H(+)-K(+)-Exchanging ATPase,
pubmed-meshheading:17706386-Indomethacin,
pubmed-meshheading:17706386-Maytenus,
pubmed-meshheading:17706386-Mucus,
pubmed-meshheading:17706386-Nitrates,
pubmed-meshheading:17706386-Nitric Oxide,
pubmed-meshheading:17706386-Nitrites,
pubmed-meshheading:17706386-Plant Leaves,
pubmed-meshheading:17706386-Protective Agents,
pubmed-meshheading:17706386-Rats,
pubmed-meshheading:17706386-Rats, Wistar,
pubmed-meshheading:17706386-Stomach Ulcer
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pubmed:year |
2007
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pubmed:articleTitle |
Flavonoid-rich fraction of Maytenus ilicifolia Mart. ex. Reiss protects the gastric mucosa of rodents through inhibition of both H+,K+ -ATPase activity and formation of nitric oxide.
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pubmed:affiliation |
Department of Pharmacology, Sector of Biological Sciences, Universidade Federal do Paraná, Curitiba, PR, Brazil.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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