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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2007-10-5
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pubmed:abstractText |
Ulcerative colitis is characterized by relapsing mucosal inflammation where the lesions include tissue-damaging granulocytes. In addition, T cells and natural killer (NK) cells play important pathophysiologic roles. Chemokines are a large family of peptides that play key roles in the regulation of inflammation. The CXC-chemokines, growth-related oncogene (GRO)-alpha/CXCL1 and interleukin (IL)-8/CXCL8, both recruit neutrophils and possess mitogenic properties, whereas the interferon-dependent CXC-chemokines monokine induced by gamma-interferon (MIG)/CXCL9, interferon-gamma inducible protein of 10 kD/CXCL10, and IFN-inducible T cell alpha chemoattractant/CXCL11 recruit and activate T cells and NK cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenal Cortex Hormones,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/CXCL1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CXCL10 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CXCL9 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CXCL1,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CXCL10,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CXCL9,
http://linkedlifedata.com/resource/pubmed/chemical/Gastrointestinal Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-8,
http://linkedlifedata.com/resource/pubmed/chemical/Prednisolone
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0179-1958
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1421-7
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pubmed:meshHeading |
pubmed-meshheading:17703315-Administration, Topical,
pubmed-meshheading:17703315-Adrenal Cortex Hormones,
pubmed-meshheading:17703315-Adult,
pubmed-meshheading:17703315-Aged,
pubmed-meshheading:17703315-Anti-Inflammatory Agents,
pubmed-meshheading:17703315-Biological Markers,
pubmed-meshheading:17703315-Chemokine CXCL1,
pubmed-meshheading:17703315-Chemokine CXCL10,
pubmed-meshheading:17703315-Chemokine CXCL9,
pubmed-meshheading:17703315-Colitis, Ulcerative,
pubmed-meshheading:17703315-Colon,
pubmed-meshheading:17703315-Colonoscopy,
pubmed-meshheading:17703315-Down-Regulation,
pubmed-meshheading:17703315-Enema,
pubmed-meshheading:17703315-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:17703315-Female,
pubmed-meshheading:17703315-Gastrointestinal Agents,
pubmed-meshheading:17703315-Humans,
pubmed-meshheading:17703315-Immunohistochemistry,
pubmed-meshheading:17703315-Interleukin-8,
pubmed-meshheading:17703315-Male,
pubmed-meshheading:17703315-Middle Aged,
pubmed-meshheading:17703315-Perfusion,
pubmed-meshheading:17703315-Prednisolone,
pubmed-meshheading:17703315-Severity of Illness Index,
pubmed-meshheading:17703315-Time Factors,
pubmed-meshheading:17703315-Treatment Outcome
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pubmed:year |
2007
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pubmed:articleTitle |
The proinflammatory CXC-chemokines GRO-alpha/CXCL1 and MIG/CXCL9 are concomitantly expressed in ulcerative colitis and decrease during treatment with topical corticosteroids.
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pubmed:affiliation |
Department of Clinical Sciences Lund, BMC B14, Tornavagen 10, 221 84, Lund, Sweden. Arne.Egesten@med.lu.se
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pubmed:publicationType |
Journal Article,
Controlled Clinical Trial,
Research Support, Non-U.S. Gov't
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